Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors.
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| Title: | Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors. |
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| Authors: | Tejwani L; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: tejwani.leon@gmail.com., Heffner CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Balak C; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Skuja LL; Denali Therapeutics Inc., South San Francisco, CA, USA., Tatarakis D; Denali Therapeutics Inc., South San Francisco, CA, USA., Rana A; Denali Therapeutics Inc., South San Francisco, CA, USA., Yu SB; Denali Therapeutics Inc., South San Francisco, CA, USA., Fitzgerald GA; Denali Therapeutics Inc., South San Francisco, CA, USA., Ha C; Denali Therapeutics Inc., South San Francisco, CA, USA., Lunkes de Melo G; Denali Therapeutics Inc., South San Francisco, CA, USA., Sun EW; Denali Therapeutics Inc., South San Francisco, CA, USA., Simon MJ; Denali Therapeutics Inc., South San Francisco, CA, USA., Dugas JC; Denali Therapeutics Inc., South San Francisco, CA, USA., Chow J; Denali Therapeutics Inc., South San Francisco, CA, USA., Thomsen E; Denali Therapeutics Inc., South San Francisco, CA, USA., Sarrafha L; Denali Therapeutics Inc., South San Francisco, CA, USA., Liang E; Denali Therapeutics Inc., South San Francisco, CA, USA., Gould N; Denali Therapeutics Inc., South San Francisco, CA, USA., Suh J; Denali Therapeutics Inc., South San Francisco, CA, USA., Sandmann T; Denali Therapeutics Inc., South San Francisco, CA, USA., Glass CK; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: gilbert.dipaolo@gmail.com. |
| Source: | Immunity [Immunity] 2026 Aug 11; Vol. 59 (8), pp. 2164-2183.e11. Date of Electronic Publication: 2026 Aug 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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