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Integrative cfDNA profiling from low-pass whole-genome sequencing enables tissue-of-origin prediction in cancer.

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Title: Integrative cfDNA profiling from low-pass whole-genome sequencing enables tissue-of-origin prediction in cancer.
Authors: Zhang Y; Department of Breast Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Liu L; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China., Bao H; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China., Xu K; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China., Zhang H; Thoracic Surgery Laboratory, Xuzhou Medical University, Xuzhou, China.; Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Wang S; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China., Chang S; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China., Zhu D; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China., Huang Z; Department of Pathology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China., Wang Z; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China., Yang L; Colorectal Center, Jiangsu Cancer Hospital, Nanjing, China., Zhang B; Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Tao J; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China., Liang W; Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Chen J; Department of Clinical Laboratory, Guangdong Provincial People's Hospital, Guangzhou, China., Yang S; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China., Wu X; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China., Shao Y; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China. yang.shao@geneseeq.com.; School of Public Health, Nanjing Medical University, Nanjing, China. yang.shao@geneseeq.com., Wang W; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. wang.wenquan@zs-hospital.sh.cn., Zhu D; Department of Rare Tumors, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. zhudy@sd-cancer.com.
Source: Molecular biomedicine [Mol Biomed] 2026 Aug 05; Vol. 7 (1). Date of Electronic Publication: 2026 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative cfDNA profiling from low-pass whole-genome sequencing enables tissue-of-origin prediction in cancer.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Breast Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Bao+H%22">Bao H</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Thoracic Surgery Laboratory, Xuzhou Medical University, Xuzhou, China.; Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Chang+S%22">Chang S</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhu+D%22">Zhu D</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; Department of Pathology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Colorectal Center, Jiangsu Cancer Hospital, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tao+J%22">Tao J</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Liang+W%22">Liang W</searchLink>; Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Clinical Laboratory, Guangdong Provincial People's Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Shao+Y%22">Shao Y</searchLink>; Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, China. yang.shao@geneseeq.com.; School of Public Health, Nanjing Medical University, Nanjing, China. yang.shao@geneseeq.com.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. wang.wenquan@zs-hospital.sh.cn.<br /><searchLink fieldCode="AU" term="%22Zhu+D%22">Zhu D</searchLink>; Department of Rare Tumors, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. zhudy@sd-cancer.com.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 Aug 05; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 Aug 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
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              Text: 2026 Aug 05
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