Implementation and outcomes of drug response assessments for inhaled hypertonic saline in bronchiectasis: a post hoc analysis of the CLEAR trial.

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Title: Implementation and outcomes of drug response assessments for inhaled hypertonic saline in bronchiectasis: a post hoc analysis of the CLEAR trial.
Authors: McLeese RH; Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Queen's University Belfast, Belfast, UK., O'Neill B; Institute of Nursing and Health Research, Ulster University, Belfast, UK., McAuley DF; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Clarke M; Centre for Public Health, Queen's University Belfast, Belfast, UK.; Northern Ireland Clinical Trials Unit, Belfast, UK., Jackson A; Northern Ireland Clinical Trials Unit, Belfast, UK., Campbell C; Northern Ireland Clinical Trials Unit, Belfast, UK., Ferguson K; HSC Western Health and Social Care Trust, Londonderry, UK., McChrystal R; Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Queen's University Belfast, Belfast, UK., De Soyza A; Population and Health Science Institute, Newcastle University and NIHR Biomedical Research Centre for Ageing, Freeman Hospital, Newcastle upon Tyne, UK., Chalmers JD; Scottish Centre for Respiratory Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Copeland F; PCD Family Support Group, Ciliopathy Alliance, Milton Keynes, UK., Elborn JS; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Bradley JM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK judy.bradley@qub.ac.uk.
Corporate Authors: CLEAR Investigator Team
Source: Thorax [Thorax] 2026 Aug 05. Date of Electronic Publication: 2026 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 0417353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3296 (Electronic) Linking ISSN: 00406376 NLM ISO Abbreviation: Thorax Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Implementation and outcomes of drug response assessments for inhaled hypertonic saline in bronchiectasis: a post hoc analysis of the CLEAR trial.
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  Data: <searchLink fieldCode="AU" term="%22McLeese+RH%22">McLeese RH</searchLink>; Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22O'Neill+B%22">O'Neill B</searchLink>; Institute of Nursing and Health Research, Ulster University, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McAuley+DF%22">McAuley DF</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Clarke+M%22">Clarke M</searchLink>; Centre for Public Health, Queen's University Belfast, Belfast, UK.; Northern Ireland Clinical Trials Unit, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Jackson+A%22">Jackson A</searchLink>; Northern Ireland Clinical Trials Unit, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+C%22">Campbell C</searchLink>; Northern Ireland Clinical Trials Unit, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Ferguson+K%22">Ferguson K</searchLink>; HSC Western Health and Social Care Trust, Londonderry, UK.<br /><searchLink fieldCode="AU" term="%22McChrystal+R%22">McChrystal R</searchLink>; Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22De+Soyza+A%22">De Soyza A</searchLink>; Population and Health Science Institute, Newcastle University and NIHR Biomedical Research Centre for Ageing, Freeman Hospital, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Chalmers+JD%22">Chalmers JD</searchLink>; Scottish Centre for Respiratory Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Copeland+F%22">Copeland F</searchLink>; PCD Family Support Group, Ciliopathy Alliance, Milton Keynes, UK.<br /><searchLink fieldCode="AU" term="%22Elborn+JS%22">Elborn JS</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Bradley+JM%22">Bradley JM</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK judy.bradley@qub.ac.uk.
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        Value: 10.1136/thorax-2025-224572
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              Text: 2026 Aug 05
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