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Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMs.

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Title: Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMs.
Authors: Mathisen GH; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway., Whaley P; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Lancaster Environment Centre, Lancaster University, Lancaster, UK., Kopainsky B; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; System Dynamics Group, University of Bergen, Bergen, Norway., Ames HM; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway., Hoffmann S; Evidence-based toxicology collaboration (EBTC), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.; Seh consulting + services, Paderborn, Germany., Husøy T; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway., Jones LB; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; School of Sociological Studies, Politics and International Relations, University of Sheffield, Sheffield, UK., Svendsen C; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway., Vist GE; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway., Bloch D; Department of Pesticides Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Cavoski A; Birmingham Law School, University of Birmingham, UK., Chiu WA; Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA., Davies HG; Washington State Department of Health, Tumwater, WA, USA., Giusti A; Cosmetics Europe Avenue Herrmann-Debroux 40, 1160, Auderghem, Belgium., Hartung T; Center for Alternatives to Animal Testing (CAAT), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.; CAAT Europe, University of Konstanz, Konstanz, Germany., Hogberg HT; Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Kwon S; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Osborne OJ; Chemical Risk Assessment Team, Science Evidence and Research Division, Food Standards Agency, Westminster, London, United Kingdom., Rooney AA; Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Rousselle C; ANSES/DAEI-French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre et Marie Curie, Maisons-Alfort Cedex, 94701, France., Sass JB; Natural Resources Defense Council, Washington, DC, USA., Simanainen U; European Chemicals Agency, Helsinki, Finland., Thayer KA; Office of Environmental Health Hazard Assessment, 1001 I street, Sacramento, California, 95814, USA., Wikoff D; ToxStrategies, Asheville, NC, USA., Bearth A; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; HF Partners, Tièchestrasse 63, 8037, Zurich, Switzerland.
Source: NAM journal [NAM J] 2026 Jul 20; Vol. 2, pp. 100118. Date of Electronic Publication: 2026 Jul 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9919013695506676 Publication Model: eCollection Cited Medium: Internet ISSN: 3050-6204 (Electronic) Linking ISSN: 30506204 NLM ISO Abbreviation: NAM J Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mathisen+GH%22">Mathisen GH</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Whaley+P%22">Whaley P</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Lancaster Environment Centre, Lancaster University, Lancaster, UK.<br /><searchLink fieldCode="AU" term="%22Kopainsky+B%22">Kopainsky B</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; System Dynamics Group, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Ames+HM%22">Ames HM</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Hoffmann+S%22">Hoffmann S</searchLink>; Evidence-based toxicology collaboration (EBTC), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.; Seh consulting + services, Paderborn, Germany.<br /><searchLink fieldCode="AU" term="%22Husøy+T%22">Husøy T</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Jones+LB%22">Jones LB</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; School of Sociological Studies, Politics and International Relations, University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Svendsen+C%22">Svendsen C</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Vist+GE%22">Vist GE</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bloch+D%22">Bloch D</searchLink>; Department of Pesticides Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Cavoski+A%22">Cavoski A</searchLink>; Birmingham Law School, University of Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Chiu+WA%22">Chiu WA</searchLink>; Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Davies+HG%22">Davies HG</searchLink>; Washington State Department of Health, Tumwater, WA, USA.<br /><searchLink fieldCode="AU" term="%22Giusti+A%22">Giusti A</searchLink>; Cosmetics Europe Avenue Herrmann-Debroux 40, 1160, Auderghem, Belgium.<br /><searchLink fieldCode="AU" term="%22Hartung+T%22">Hartung T</searchLink>; 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ANSES/DAEI-French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre et Marie Curie, Maisons-Alfort Cedex, 94701, France.<br /><searchLink fieldCode="AU" term="%22Sass+JB%22">Sass JB</searchLink>; Natural Resources Defense Council, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Simanainen+U%22">Simanainen U</searchLink>; European Chemicals Agency, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Thayer+KA%22">Thayer KA</searchLink>; Office of Environmental Health Hazard Assessment, 1001 I street, Sacramento, California, 95814, USA.<br /><searchLink fieldCode="AU" term="%22Wikoff+D%22">Wikoff D</searchLink>; ToxStrategies, Asheville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bearth+A%22">Bearth A</searchLink>; Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.; HF Partners, Tièchestrasse 63, 8037, Zurich, Switzerland.
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