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DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.

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Title: DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.
Authors: Wang P; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Foo N; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Su C; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Leung NYT; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Song SW; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Seres G; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Sapanel Y; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Hooi L; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Wong A; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Ong YH; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Rai P; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Park H; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Chew HSJ; Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wang LYT; Well Programme, Alexandra Hospital, National University Health System, Singapore, Singapore.; Department of Cardiology, National University Heart Centre, National University Health System, Singapore, Singapore., Lee JWJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore.; iHealthtech, National University of Singapore, Singapore, Singapore., Tadeo X; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore., Ho D; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The Bia-Echo Asia Centre for Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Source: PloS one [PLoS One] 2026 Aug 12; Vol. 21 (8), pp. e0354234. Date of Electronic Publication: 2026 Aug 12 (Print Publication: 2026).
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.
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  Data: <searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Foo+N%22">Foo N</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Su+C%22">Su C</searchLink>; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Leung+NYT%22">Leung NYT</searchLink>; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Song+SW%22">Song SW</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Seres+G%22">Seres G</searchLink>; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sapanel+Y%22">Sapanel Y</searchLink>; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hooi+L%22">Hooi L</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+A%22">Wong A</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+YH%22">Ong YH</searchLink>; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Rai+P%22">Rai P</searchLink>; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chew+HSJ%22">Chew HSJ</searchLink>; Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+LYT%22">Wang LYT</searchLink>; Well Programme, Alexandra Hospital, National University Health System, Singapore, Singapore.; Department of Cardiology, National University Heart Centre, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+JWJ%22">Lee JWJ</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore.; iHealthtech, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tadeo+X%22">Tadeo X</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+D%22">Ho D</searchLink>; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; The Bia-Echo Asia Centre for Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Aug 12; Vol. 21 (8), pp. e0354234. <i>Date of Electronic Publication: </i>2026 Aug 12 (<i>Print Publication: </i>2026).
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