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Dry eye disease in axial spondyloarthritis: heterogeneous ocular surface dysfunction involving tear film instability and tear production from the AIDA network registry.

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Title: Dry eye disease in axial spondyloarthritis: heterogeneous ocular surface dysfunction involving tear film instability and tear production from the AIDA network registry.
Authors: Caggiano V; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy., Vitale A; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy., Sbalchiero J; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy., Tufan A; Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye., Guaracha-Basañez GA; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Kawakami-Campos PA; Department of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Hinojosa-Azaola A; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Duran R; Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye., Kucuk H; Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye., Ragab G; Rheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt., Ruscitti P; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Lopalco G; Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy., Karamanakos A; Department of Rheumatology, Evangelismos General Hospital, Athens, Greece., Fotis L; Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Ghanema M; Rheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt., Cipriani P; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Morrone M; Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy., Dimouli A; Department of Rheumatology, Evangelismos General Hospital, Athens, Greece., Kourtesi K; Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Tharwat S; Rheumatology and Immunology Unit, Department of Internal Medicine, Mansoura University, Mansoura, Egypt.; Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt., Moshrif A; Department of Rheumatology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Sota J; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy., Mayo-Juanatey A; Department of Rheumatology, Doctor Peset University Hospital, Valencia, Spain., Boyarchuk O; Department of Children's Diseases and Pediatric Surgery, Ternopil Regional Children's Hospital, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine., Edrees A; Division of Rheumatology, University of Missouri-Kansas City, Kansas City, MO, United States., Barone P; Pediatric Rheumatology Unit, Department of integrated Maternal-Child and Reproduction Activity, AOU 'Policlinico-San Marco', Catania, Italy., Carubbi F; Internal Medicine and Nephrology Division, Department of Life, Health and Environmental Sciences, ASL1 Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, University of L'Aquila, L'Aquila, Italy., Chimenti MS; Rheumatology, Allergology and Clinical Immunology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Conforti A; U.O. Medicina Generale, Ospedale San Paolo di Civitavecchia, ASL Roma 4, Civitavecchia, Italy., Thabet M; Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia., Opris-Belinski D; Department of Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Erten Ş; Department of Rheumatology, Ankara Yıldırım Beyazıt University, Ankara Bilkent City Hospital, Ankara-Tüürkiy., Hegazy MT; Rheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.; Rheumatology Unit, Department of Internal Medicine, Jahra Hospital, Al Jahra, Kuwait., Mazzei MA; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy., Piscitello C; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy., Frediani B; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy., Balistreri A; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Cifuentes-González C; Department of Ocular Immunology, Ophthalmology Research Center, SIGMA Clinic, Cali, Colombia.; Centre of Excellence in Ocular Inflammation, Colombian Visual Science and Translational Eye Research Institute (CERI), Bogotá, Colombia., de-la-Torre A; Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Cantarini L; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy., Fabiani C; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Source: Frontiers in medicine [Front Med (Lausanne)] 2026 Aug 03; Vol. 13, pp. 1851512. Date of Electronic Publication: 2026 Aug 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
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  Data: Dry eye disease in axial spondyloarthritis: heterogeneous ocular surface dysfunction involving tear film instability and tear production from the AIDA network registry.
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  Data: <searchLink fieldCode="AU" term="%22Caggiano+V%22">Caggiano V</searchLink>; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Vitale+A%22">Vitale A</searchLink>; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Sbalchiero+J%22">Sbalchiero J</searchLink>; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Tufan+A%22">Tufan A</searchLink>; Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye.<br /><searchLink fieldCode="AU" term="%22Guaracha-Basañez+GA%22">Guaracha-Basañez GA</searchLink>; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Kawakami-Campos+PA%22">Kawakami-Campos PA</searchLink>; Department of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Hinojosa-Azaola+A%22">Hinojosa-Azaola A</searchLink>; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Duran+R%22">Duran R</searchLink>; Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye.<br /><searchLink fieldCode="AU" term="%22Kucuk+H%22">Kucuk H</searchLink>; Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye.<br /><searchLink fieldCode="AU" term="%22Ragab+G%22">Ragab G</searchLink>; Rheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Ruscitti+P%22">Ruscitti P</searchLink>; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Lopalco+G%22">Lopalco G</searchLink>; Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Karamanakos+A%22">Karamanakos A</searchLink>; Department of Rheumatology, Evangelismos General Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Fotis+L%22">Fotis L</searchLink>; Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Ghanema+M%22">Ghanema M</searchLink>; Rheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Cipriani+P%22">Cipriani P</searchLink>; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Morrone+M%22">Morrone M</searchLink>; Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Dimouli+A%22">Dimouli A</searchLink>; Department of Rheumatology, Evangelismos General Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Kourtesi+K%22">Kourtesi K</searchLink>; Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Tharwat+S%22">Tharwat S</searchLink>; Rheumatology and Immunology Unit, Department of Internal Medicine, Mansoura University, Mansoura, Egypt.; Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Moshrif+A%22">Moshrif A</searchLink>; Department of Rheumatology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Sota+J%22">Sota J</searchLink>; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN-RITA) Center, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Mayo-Juanatey+A%22">Mayo-Juanatey A</searchLink>; Department of Rheumatology, Doctor Peset University Hospital, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Boyarchuk+O%22">Boyarchuk O</searchLink>; Department of Children's Diseases and Pediatric Surgery, Ternopil Regional Children's Hospital, I. 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              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 2296-858X
          Numbering:
            – Type: volume
              Value: 13
          Titles:
            – TitleFull: Frontiers in medicine
              Type: main
ResultId 1