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Boldine inhibits SARM1 NADase Activity and Preserves Axonal Integrity After Nerve Injury.

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Title: Boldine inhibits SARM1 NADase Activity and Preserves Axonal Integrity After Nerve Injury.
Authors: Burrell JC; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.; Center for Innovation & Precision Dentistry, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Oral & Maxillofacial Surgery, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA., Latona TT; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Garcia H; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Clizbe DR; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA., Tatarchuk MM; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA., Zhou L; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA., Toro CA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Spinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA., Olivarez AN; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Nguyen PV; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA., Yang CZ; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA., Bittner GD; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Cardozo CP; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Spinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA., Cullen DK; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.; Center for Innovation & Precision Dentistry, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 30. Date of Electronic Publication: 2026 Jul 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Boldine inhibits SARM1 NADase Activity and Preserves Axonal Integrity After Nerve Injury.
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  Data: <searchLink fieldCode="AU" term="%22Burrell+JC%22">Burrell JC</searchLink>; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.; Center for Innovation & Precision Dentistry, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Oral & Maxillofacial Surgery, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Latona+TT%22">Latona TT</searchLink>; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+H%22">Garcia H</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Clizbe+DR%22">Clizbe DR</searchLink>; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tatarchuk+MM%22">Tatarchuk MM</searchLink>; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Toro+CA%22">Toro CA</searchLink>; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Spinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Olivarez+AN%22">Olivarez AN</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+PV%22">Nguyen PV</searchLink>; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yang+CZ%22">Yang CZ</searchLink>; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bittner+GD%22">Bittner GD</searchLink>; Department of Neuroscience, University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Cardozo+CP%22">Cardozo CP</searchLink>; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Spinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cullen+DK%22">Cullen DK</searchLink>; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.; Center for Innovation & Precision Dentistry, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA, USA.
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