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IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states.

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Title: IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states.
Authors: Doultsinos D; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. dimitrios.doultsinos@nds.ox.ac.uk., Tomljanovic I; Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands., Pilalis E; e-NIOS PC, Kallithea-Athens, Greece., Abusamra SM; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Alshalalfa M; Veracyte, South San Francisco, CA, USA., Parmentier R; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Department of Urology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland., Ahire V; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Bridges IE; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Figiel S; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester J; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Leach D; Imperial College London, London, UK., Nandakumar A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Wan R; Department of Urology, UCSF, San Francisco, CA, USA., Zekri Y; Division of Oncogenomics, The Netherlands Cancer Insitute, 1066 CX, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands., Zhang J; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, Bellinzona, TI, 6500, Switzerland., Bevan CL; Imperial College London, London, UK., O'Neill E; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Lamb AD; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Macauley V; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Theurillat JP; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, Bellinzona, TI, 6500, Switzerland., Urbanucci A; Center for Cancer Eradication Research, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere, Finland.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Karnes RJ; Mayo Clinic Dept of Urology, Rochester, MN, USA., Spratt DE; University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Davicioni E; Veracyte, South San Francisco, CA, USA., Quigley D; Department of Urology, UCSF, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA., Zwart W; Division of Oncogenomics, The Netherlands Cancer Insitute, 1066 CX, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands., Le Magnen C; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Department of Urology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland., Chatziioannou A; e-NIOS PC, Kallithea-Athens, Greece.; Center of Systems Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Mills IG; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. ian.mills@nds.ox.ac.uk.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Oct; Vol. 18 (10), pp. 3898-3938. Date of Electronic Publication: 2026 Aug 22.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states.
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  Data: <searchLink fieldCode="AU" term="%22Doultsinos+D%22">Doultsinos D</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. dimitrios.doultsinos@nds.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Tomljanovic+I%22">Tomljanovic I</searchLink>; Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pilalis+E%22">Pilalis E</searchLink>; e-NIOS PC, Kallithea-Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Abusamra+SM%22">Abusamra SM</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Alshalalfa+M%22">Alshalalfa M</searchLink>; Veracyte, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Parmentier+R%22">Parmentier R</searchLink>; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Department of Urology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ahire+V%22">Ahire V</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bridges+IE%22">Bridges IE</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Figiel+S%22">Figiel S</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hester+J%22">Hester J</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Leach+D%22">Leach D</searchLink>; Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nandakumar+A%22">Nandakumar A</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wan+R%22">Wan R</searchLink>; Department of Urology, UCSF, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zekri+Y%22">Zekri Y</searchLink>; Division of Oncogenomics, The Netherlands Cancer Insitute, 1066 CX, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, Bellinzona, TI, 6500, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bevan+CL%22">Bevan CL</searchLink>; Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Neill+E%22">O'Neill E</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lamb+AD%22">Lamb AD</searchLink>; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Macauley+V%22">Macauley V</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Theurillat+JP%22">Theurillat JP</searchLink>; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, Bellinzona, TI, 6500, Switzerland.<br /><searchLink fieldCode="AU" term="%22Urbanucci+A%22">Urbanucci A</searchLink>; Center for Cancer Eradication Research, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere, Finland.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Karnes+RJ%22">Karnes RJ</searchLink>; Mayo Clinic Dept of Urology, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Spratt+DE%22">Spratt DE</searchLink>; University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Davicioni+E%22">Davicioni E</searchLink>; Veracyte, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Quigley+D%22">Quigley D</searchLink>; Department of Urology, UCSF, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zwart+W%22">Zwart W</searchLink>; Division of Oncogenomics, The Netherlands Cancer Insitute, 1066 CX, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Le+Magnen+C%22">Le Magnen C</searchLink>; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Department of Urology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chatziioannou+A%22">Chatziioannou A</searchLink>; e-NIOS PC, Kallithea-Athens, Greece.; Center of Systems Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Mills+IG%22">Mills IG</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. ian.mills@nds.ox.ac.uk.
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