Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.

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Title: Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.
Authors: van der Veen T; Division of Psychiatry, University College London, London, UK.; Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, NIH, US Dept of HHS, Bethesda MD USA.; These authors contributed as first authors: Tracey van der Veen, Markos Tesfaye., Tesfaye M; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Center for Precision Psychiatry, University of Oslo, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.; These authors contributed as first authors: Tracey van der Veen, Markos Tesfaye., Yang JMK; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.; These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina., Boltz T; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina., David FS; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.; These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina., Crinion S; Centre for Neuroimaging, Cognition and Genomics, School of Biological and Chemical Sciences and School of Psychology, University of Galway, Galway, Ireland.; These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina., Koromina M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina., Andlauer TFM; Global Computational Biology and Data Sciences, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach an der Riß, Germany.; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany., Bigdeli TB; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; VA NY Harbor Healthcare System, Brooklyn, NY, USA.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Coombes BJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Greenwood TA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Panagiotaropoulou G; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany., Parker N; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Center for Precision Psychiatry, University of Oslo, Oslo, Norway., Sung H; Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, NIH, US Dept of HHS, Bethesda MD USA., Bass N; Division of Psychiatry, University College London, London, UK., Coleman JRI; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; NIHR Maudsley BRC, King's College London, London, UK., Guzman-Parra J; Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain., Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., McGrouther CC; New York University, New York, NY, USA., Mitchell BL; Brain and Mental Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Rangan AV; New York University, New York, NY, USA.; Flatiron Institute, New York, NY, USA., Scott K; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Shadrin A; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Center for Precision Psychiatry, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway., Smith DJ; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Vreeker A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC Sophia Children Hospital, Erasmus University, Rotterdam, The Netherlands.; Psychiatry, Brain Center UMC Utrecht, Utrecht, The Netherlands.; Department of Psychology Education and Child Studies, Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam, The Netherlands., Adorjan K; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland., Albani D; Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy., Alemany S; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Alliey-Rodriguez N; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.; Northwestern University, Chicago, IL, USA., Antoniou A; National and Kapodistrian University of Athens, 2nd Department of Psychiatry, Attikon General Hospital, Athens, Greece., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Beins EC; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Boks MP; Psychiatry, Brain Center UMC Utrecht, Utrecht, The Netherlands., Bosch R; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Programa SJD MIND Escoles, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain., Brumpton BM; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Brunkhorst-Kanaan N; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Byerley W; Psychiatry, University of California San Francisco, San Francisco, CA, USA., Cabana-Domínguez J; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Cairns MJ; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton, NSW, Australia., Carpiniello B; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Casas M; Programa SJD MIND Escoles, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.; Fundació Privada d'Investigació Sant Pau (FISP), Barcelona, Spain., Cervantes P; Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, QC, Canada., Chatzinakos C; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Clarke TK; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Claus I; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Cruceanu C; Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, QC, Canada.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Cuellar-Barboza A; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Czerski PM; Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland., Dafnas K; National and Kapodistrian University of Athens, 2nd Department of Psychiatry, Attikon General Hospital, Athens, Greece., Dale AM; Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA., Dalkner N; Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria., DePaulo JR; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Degenhardt F; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany., Djurovic S; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway., Escott-Price V; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Fanous AH; Department of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.; Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ, USA.; Banner-University Medical Center, Phoenix, AZ, USA., Fellendorf FT; Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria., Ferrier IN; Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK., Forty L; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Frei O; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Freimer NB; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Garnham J; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Gizer IR; Department of Psychological Sciences, University of Missouri, Columbia, MO, USA., Gordon SD; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Gordon-Smith K; Psychological Medicine, University of Worcester, Worcester, UK., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hamshere ML; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Harder A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hautzinger M; Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Hellgren D; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Herms S; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Hickie IB; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Holmans PA; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Jamain S; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Créteil, France., Jonsson L; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Kennedy JL; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Kittel-Schneider S; Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland.; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Knowles JA; Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA., Koch E; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Center for Precision Psychiatry, University of Oslo, Oslo, Norway., Kogevinas M; ISGlobal, Barcelona, Spain., Kranz TM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Kushner SA; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Lavebratt C; Translational Psychiatry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Lawrence J; Psychiatry, North East London NHS Foundation Trust, Ilford, UK., Leber M; Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany., Lind PA; Brain and Mental Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Lucae S; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Lundberg M; Translational Psychiatry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., MacIntyre DJ; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK., Maier W; Department of Psychiatry and Psychotherapy, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Maihofer AX; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Malaspina D; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Manchia M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Italy.; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada., Maratou E; National and Kapodistrian University of Athens, Medical School, Clinical Biochemistry Laboratory, Attikon General Hospital, Athens, Greece., Martinsson L; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Centre for Psychiatry Research, SLSO Region Stockholm, Sweden., McInnis MG; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., McKay JD; Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France., Medeiros H; Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA., Meyer-Lindenberg A; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; German Centre for Mental Health (DZPG), Germany., Millischer V; Translational Psychiatry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, Medical University of Vienna, Austria.; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria., Morris DW; Centre for Neuroimaging and Cognitive Genomics (NICOG), School of Biological and Chemical Sciences, University of Galway, Galway, Ireland., Moutsatsou P; National and Kapodistrian University of Athens, Medical School, Clinical Biochemistry Laboratory, Attikon General Hospital, Athens, Greece., Mühleisen TW; Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., O'Donovan C; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Olsen CM; Population Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain., Pardiñas AF; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Perry A; Psychological Medicine, University of Worcester, Worcester, UK., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Italy., Potash JB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Quested D; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK., Rapaport MH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Regeer EJ; Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, The Netherlands., Rice JP; Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA., Rivera M; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain.; Institute of Neurosciences 'Federico Olóriz', Biomedical Research Center (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain., Schulte EC; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; German Center for Mental Health (DZPG), partner site Munich/Augsburg, 80336, Munich, Germany., Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Shilling PD; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Sindermann L; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Sirignano L; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Siskind D; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Slaney C; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Smeland OB; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Center for Precision Psychiatry, University of Oslo, Oslo, Norway., Sobell JL; Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA., Artigas MS; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain., Stein DJ; SAMRC Unit on Risk and Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Stein F; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Swiatkowska B; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland., Thorp JG; Brain and Mental Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Toma C; Neuroscience Research Australia, Sydney, NSW, Australia.; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid and CSIC, Madrid, Spain., Tondo L; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Tooney PA; School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, NSW, Australia., Vawter MP; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA., Vedder H; Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany., Walters JTR; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Young AH; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent, UK., Zandi PP; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zillich L; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Adolfsson R; Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden., Alfredsson L; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Backlund L; Translational Psychiatry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Bellivier F; Université Paris Cité, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS-1144, Paris, France.; APHP Nord, DMU Neurosciences, GHU Saint Louis-Lariboisiére-Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France., Bengesser S; Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria., Berrettini WH; Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Blackwood D; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Boehnke M; Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Breen G; NIHR Maudsley BRC, King's College London, London, UK.; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Carr VJ; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Catts S; University of Queensland, Brisbane, QLD, Australia., Cichon S; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Corvin A; Neuropsychiatric Genetics Research Group, Dept of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Craddock N; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dikeos D; National and Kapodistrian University of Athens, 1st Department of Psychiatry, Eginition Hospital, Athens, Greece., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA., Etain B; Université Paris Cité, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS-1144, Paris, France.; APHP Nord, DMU Neurosciences, GHU Saint Louis-Lariboisiére-Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France., Ferentinos P; National and Kapodistrian University of Athens, 2nd Department of Psychiatry, Attikon General Hospital, Athens, Greece.; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Frye M; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Fullerton JM; Neuroscience Research Australia, Sydney, NSW, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Gawlik M; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Gershon ES; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Goes FS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Green MJ; Neuroscience Research Australia, Sydney, NSW, Australia.; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Hauser J; Department of Psychiatry, Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland., Henskens FA; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia., Hjerling-Leffler J; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Jones I; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Jones LA; Psychological Medicine, University of Worcester, Worcester, UK., Kahn RS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Psychiatry, Brain Center UMC Utrecht, Utrecht, The Netherlands., Kelsoe JR; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Kirov G; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Kobayashi N; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Landén M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Leboyer M; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Créteil, France., Lenger M; Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria., Li QS; Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.; JRD Data Science, Janssen Research and Development, LLC, Titusville, NJ, USA., Lissowska J; Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Loughland C; University of Newcastle, Newcastle, NSW, Australia., Luykx JJ; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands., Martin NG; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Psychology, The University of Queensland, Brisbane, QLD, Australia., Mathews CA; Department of Psychiatry and Genetics Institute, University of Florida, Gainesville, FL, USA., Mayoral F; Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain., McElroy SL; Research Institute, Lindner Center of HOPE, Mason, OH, USA., McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK., Medland SE; Brain and Mental Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Psychology and Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia., Melle I; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, Norway., Mitchell PB; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Morken G; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Psychiatry, St Olavs University Hospital, Trondheim, Norway., Myers RM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Möser C; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; University of Liverpool, Liverpool, UK., Neale BM; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Nurnberger JI; Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., O'Donovan MC; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Oedegaard KJ; Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway.; Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway., Olsson T; Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden., Owen MJ; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Paciga SA; Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA., Pantelis C; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, VIC, Australia.; Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, Australia., Pato CN; Rutgers Health, Rutgers University, Piscataway, New Jersey, USA., Pato MT; Rutgers Health, Rutgers University, Piscataway, New Jersey, USA., Patrinos GP; University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, Patras, Greece.; United Arab Emirates University, College of Medicine and Health Sciences, Department of Genetics and Genomics, Al-Ain, United Arab Emirates.; United Arab Emirates University, Zayed Center for Health Sciences, Al-Ain, United Arab Emirates.; Erasmus University Medical Center Rotterdam, Faculty of Medicine and Health Sciences, Department of Pathology, Clinical Bioinformatics Unit, Rotterdam, The Netherlands., Pawlak JM; Department of Psychiatry, Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland., Perlis R; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Ramos-Quiroga JA; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Reininghaus EZ; Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria., Ribasés M; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ripke S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Rouleau GA; Department of Neurology and Neurosurgery, McGill University, Faculty of Medicine, Montreal, QC, Canada.; Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada., Schall U; Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Schalling M; Translational Psychiatry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Schofield PR; Neuroscience Research Australia, Sydney, NSW, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA., Scott LJ; Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Pritzker Neuropsychiatric Disorders Research Consortium, University of Michigan, USA., Scott RJ; The School of Biomedical Sciences and Pharmacy, Faculty of Medicine, Health and Wellbeing, University of Newcastle, Newcastle, NSW, Australia.; Cancer Detection and Therapies Program, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia., Serretti A; Department of Medicine and Surgery, Kore University of Enna, Enna, Italy.; Oasi Research Institute-IRCCS, Troina, Italy., Smoller JW; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA., Squassina A; Department of Biomedical Sciences, University of Cagliari, Italy., Stahl EA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Stordal E; Department of Psychiatry, Hospital Namsos, Namsos, Norway.; Department of Neuroscience, Norges Teknisk Naturvitenskapelige Universitet Fakultet for naturvitenskap og teknologi, Trondheim, Norway., Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Turecki G; Department of Psychiatry, McGill University, Montreal, QC, Canada., Vaaler AE; Dept of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway., Vieta E; Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Vincent JB; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Waldman ID; Department of Psychology, Emory University, Atlanta, GA, USA., Weickert CS; Neuroscience Research Australia, Sydney, NSW, Australia.; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.; Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA., Weickert TW; Neuroscience Research Australia, Sydney, NSW, Australia.; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.; Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA., Whiteman DC; Population Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Alda M; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.; National Institute of Mental Health, Klecany, Czech Republic.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., Ophoff RA; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., O'Connell KS; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Center for Precision Psychiatry, University of Oslo, Oslo, Norway.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., Mullins N; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.; Centre for Human Genetics, University of Marburg, Marburg, Germany.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., Grigoroiu-Serbanescu M; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., Edenberg HJ; Department of Biochemistry, Molecular Biology and Pharmacology, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., McMahon FJ; Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, NIH, US Dept of HHS, Bethesda MD USA.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., Andreassen OA; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Center for Precision Psychiatry, University of Oslo, Oslo, Norway.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., Di Florio A; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin., McQuillin A; Division of Psychiatry, University College London, London, UK.; These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Corporate Authors: Estonian Biobank research team, Genomic Psychiatry Cohort (GPC) Investigators, HUNT All-In Psychiatry
Source: Research square [Res Sq] 2026 Aug 26. Date of Electronic Publication: 2026 Aug 26.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-10041361/v1