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The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals.

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Title: The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals.
Authors: Lin M; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, United States of America., Chakraborty S; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America., Amorim CEG; Center for Evolution and Medicine, School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America., Nigenda-Morales SF; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, Mexico.; Department of Biological Sciences, California State University San Marcos, San Marcos, California, United States of America., Beichman AC; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America., Nuñez-Valencia PG; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, Mexico.; Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico., Mah JC; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States of America., Robinson JA; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America., Kyriazis CC; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.; Conservation Genetics, San Diego Zoo Wildlife Alliance, Escondido, California, United States of America., Huber CD; Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America., Webb AE; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America., Kocher SD; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America., Archer FI; Marine Mammal and Turtle Division, Southwest Fisheries Science Center, La Jolla, California, United States of America., Moreno-Estrada A; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, Mexico., Wayne RK; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America., Lohmueller KE; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States of America.
Source: PLoS biology [PLoS Biol] 2026 Sep 08; Vol. 24 (9), pp. e3003976. Date of Electronic Publication: 2026 Sep 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals.
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  Data: <searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Chakraborty+S%22">Chakraborty S</searchLink>; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Amorim+CEG%22">Amorim CEG</searchLink>; Center for Evolution and Medicine, School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America.<br /><searchLink fieldCode="AU" term="%22Nigenda-Morales+SF%22">Nigenda-Morales SF</searchLink>; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, Mexico.; Department of Biological Sciences, California State University San Marcos, San Marcos, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Beichman+AC%22">Beichman AC</searchLink>; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Nuñez-Valencia+PG%22">Nuñez-Valencia PG</searchLink>; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, Mexico.; Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico.<br /><searchLink fieldCode="AU" term="%22Mah+JC%22">Mah JC</searchLink>; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Robinson+JA%22">Robinson JA</searchLink>; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Kyriazis+CC%22">Kyriazis CC</searchLink>; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.; Conservation Genetics, San Diego Zoo Wildlife Alliance, Escondido, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Huber+CD%22">Huber CD</searchLink>; Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Webb+AE%22">Webb AE</searchLink>; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Kocher+SD%22">Kocher SD</searchLink>; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Archer+FI%22">Archer FI</searchLink>; Marine Mammal and Turtle Division, Southwest Fisheries Science Center, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Moreno-Estrada+A%22">Moreno-Estrada A</searchLink>; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, Mexico.<br /><searchLink fieldCode="AU" term="%22Wayne+RK%22">Wayne RK</searchLink>; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Lohmueller+KE%22">Lohmueller KE</searchLink>; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States of America.
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