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Type 1 interferon perturbates clonal competition by reshaping human blood development.

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Title: Type 1 interferon perturbates clonal competition by reshaping human blood development.
Authors: Lama C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Isakov D; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rosenberg S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Quijada-Álamo M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Saurty-Seerunghen MS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Moein S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Nozais M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Abera TA; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Sakaguchi O; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Totwani M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Freed G; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zaydon L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Poon CL; Department of Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, New York, NY, USA., Parghi N; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Kubas-Meyer A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Xie AX; Biochemistry, Structural Biology, Cell Biology, Developmental Biology and Molecular Biology Graduate Programs, Weill Cornell Medicine, New York, NY, USA.; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Omar M; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Choi D; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Castillo-Tokumori F; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Abu-Zeinah G; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Dillard A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Ganesan S; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; New York Genome Center, New York, NY, USA., Omans ND; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; New York Genome Center, New York, NY, USA.; Tri-Institutional Training Program in Computational Biology and Medicine, Memorial Sloan Kettering Cancer Center, Cornell University, Weill Cornell Medicine, New York, NY, USA., Dusaj N; Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; New York Genome Center, New York, NY, USA., Chamely P; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; New York Genome Center, New York, NY, USA., Mimitou E; Immunai, New York, NY, USA., Smibert P; 10x Genomics, Pleasanton, CA, USA., Kosiorek HE; Department of Biostatistics, Mayo Clinic Arizona, Scottsdale, AZ, USA., Dueck AC; Department of Quantitative Health Sciences and Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN, USA., Weinberg R; New York Blood Center, New York, NY, USA., Chaligne R; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Marcellino B; Myeloproliferative Neoplasms Research Consortium, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marchionni L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Patel S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Simonson P; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Landau DA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; New York Genome Center, New York, NY, USA.; Tri-Institutional Training Program in Computational Biology and Medicine, Memorial Sloan Kettering Cancer Center, Cornell University, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, New York, NY, USA., Wagenblast E; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoffman R; New York Blood Center, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nam AS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. shn9035@med.cornell.edu.; Biochemistry, Structural Biology, Cell Biology, Developmental Biology and Molecular Biology Graduate Programs, Weill Cornell Medicine, New York, NY, USA. shn9035@med.cornell.edu.; Tri-Institutional Training Program in Computational Biology and Medicine, Memorial Sloan Kettering Cancer Center, Cornell University, Weill Cornell Medicine, New York, NY, USA. shn9035@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, New York, NY, USA. shn9035@med.cornell.edu.
Source: Nature genetics [Nat Genet] 2026 Sep 15. Date of Electronic Publication: 2026 Sep 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Type 1 interferon perturbates clonal competition by reshaping human blood development.
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