Gene regulatory network analysis identifies auranofin as an anti-atherosclerotic drug.
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| Title: | Gene regulatory network analysis identifies auranofin as an anti-atherosclerotic drug. |
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| Authors: | Amadori L; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Cardiology, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Calcagno C; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kaur R; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Horstmann H; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., He T; Department of Psychiatry, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA.; VA Boston Cooperative Studies Program, MAVERIC, VA Boston Healthcare System, Boston, MA, USA., Gildea M; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Sakurai K; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chong PS; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shamailova R; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Naidu S; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hill CA; Department of Medicine, Division of Cardiology, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sajja S; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Bresciani J; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., La Forest M; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Ghotbi AA; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cardiology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.; Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Soler R; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Vascular and Endovascular Surgery, Saint-Joseph Hospital, Marseille, France., Faries C; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fisher EA; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Fayad ZA; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fillmore NR; VA Boston Cooperative Studies Program, MAVERIC, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ramos-Cejudo J; Department of Psychiatry, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA.; VA Boston Cooperative Studies Program, MAVERIC, VA Boston Healthcare System, Boston, MA, USA.; Department of Neurology, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Readhead B; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA., Dudley JT; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bjorkegren JLM; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, (Huddinge), Karolinska Institutet, Stockholm, Sweden.; Clinical Gene Networks AB, Stockholm, Sweden., Giannarelli C; Department of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA. chiara.giannarelli@nyulangone.org.; Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA. chiara.giannarelli@nyulangone.org. |
| Source: | Nature communications [Nat Commun] 2026 Sep 02; Vol. 17 (1). Date of Electronic Publication: 2026 Sep 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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