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CIO-IAA is a dual ETA/ETB receptor antagonist that suppresses endothelin-1-induced macrophage activation and inflammatory signaling.

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Title: CIO-IAA is a dual ETA/ETB receptor antagonist that suppresses endothelin-1-induced macrophage activation and inflammatory signaling.
Authors: Nguyen T; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Hoque N; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA; Department of Pharmacy, East West University, Dhaka, Bangladesh., Islam N; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Sooreni S; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Naser A; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Begum M; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Menon SN; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Jones M; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Ezewudo E; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA., Islam T; Caprico Biotechnologies, Duluth, GA, USA., Rubio-Alarcón M; Department of Pharmacology, University of Cambridge, Cambridge, UK., Rahman T; Department of Pharmacology, University of Cambridge, Cambridge, UK., Hasan R; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA. Electronic address: hasan_r@mercer.edu.
Source: Biochemical pharmacology [Biochem Pharmacol] 2026 Oct 03; Vol. 254 (Pt 3), pp. 118517. Date of Electronic Publication: 2026 Oct 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CIO-IAA is a dual ET<subscript>A</subscript>/ET<subscript>B</subscript> receptor antagonist that suppresses endothelin-1-induced macrophage activation and inflammatory signaling.
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  Data: <searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hoque+N%22">Hoque N</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA; Department of Pharmacy, East West University, Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Islam+N%22">Islam N</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sooreni+S%22">Sooreni S</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Naser+A%22">Naser A</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Begum+M%22">Begum M</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Menon+SN%22">Menon SN</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+M%22">Jones M</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ezewudo+E%22">Ezewudo E</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Islam+T%22">Islam T</searchLink>; Caprico Biotechnologies, Duluth, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rubio-Alarcón+M%22">Rubio-Alarcón M</searchLink>; Department of Pharmacology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rahman+T%22">Rahman T</searchLink>; Department of Pharmacology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hasan+R%22">Hasan R</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA. Electronic address: hasan_r@mercer.edu.
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  Data: <searchLink fieldCode="JN" term="%220101032%22">Biochemical pharmacology</searchLink> [Biochem Pharmacol] 2026 Oct 03; Vol. 254 (Pt 3), pp. 118517. <i>Date of Electronic Publication: </i>2026 Oct 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0101032 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2968 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062952%22">00062952 </searchLink><i>NLM ISO Abbreviation: </i>Biochem Pharmacol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42829115
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              Text: 2026 Oct 03
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