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FAP adipogenesis drives early spinal muscle loss in dysferlinopathy and reveals a therapeutic target.

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Title: FAP adipogenesis drives early spinal muscle loss in dysferlinopathy and reveals a therapeutic target.
Authors: Moon YJ; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.; Departments of Biochemistry and Orthopaedic Surgery, Research Institute of Clinical Medicine of Jeonbuk National University - Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Republic of Korea.; Institute for Medical Science of Jeonbuk National University Medical School, Jeonju, Republic of Korea., McCormack N; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA., Diehn T; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA., Lin S; Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA., Staedler K; Sorbonne Université, Service de Neuromyologie, Centre de référence Nord-Est-Ile-de-France, Institut de Myologie, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital 75651 Paris Cedex 13, Paris, France.; Department of Neurology, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland., Bhattacharya S; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA., Bittel DC; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA., Wang PC; Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA., Hogarth M; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Oh JS; Department of Orthopaedic Surgery, Jeonbuk National University Hospital, Jeonju, Republic of Korea., Goh TS; Department of Orthopaedic Surgery, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Republic of Korea., Min JH; Department of Rehabilitation Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Stojkovic T; Sorbonne Université, Service de Neuromyologie, Centre de référence Nord-Est-Ile-de-France, Institut de Myologie, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital 75651 Paris Cedex 13, Paris, France., Ackermann-Bonan I; Sorbonne Université, Service de Neuromyologie, Centre de référence Nord-Est-Ile-de-France, Institut de Myologie, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital 75651 Paris Cedex 13, Paris, France., Jaiswal JK; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA. jkjaiswal@cnmc.org.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. jkjaiswal@cnmc.org.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Oct; Vol. 18 (10), pp. 4034-4058. Date of Electronic Publication: 2026 Oct 12.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: FAP adipogenesis drives early spinal muscle loss in dysferlinopathy and reveals a therapeutic target.
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  Data: <searchLink fieldCode="AU" term="%22Moon+YJ%22">Moon YJ</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.; Departments of Biochemistry and Orthopaedic Surgery, Research Institute of Clinical Medicine of Jeonbuk National University - Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Republic of Korea.; Institute for Medical Science of Jeonbuk National University Medical School, Jeonju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22McCormack+N%22">McCormack N</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Diehn+T%22">Diehn T</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Staedler+K%22">Staedler K</searchLink>; Sorbonne Université, Service de Neuromyologie, Centre de référence Nord-Est-Ile-de-France, Institut de Myologie, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital 75651 Paris Cedex 13, Paris, France.; Department of Neurology, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bhattacharya+S%22">Bhattacharya S</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Bittel+DC%22">Bittel DC</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Wang+PC%22">Wang PC</searchLink>; Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Hogarth+M%22">Hogarth M</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Oh+JS%22">Oh JS</searchLink>; Department of Orthopaedic Surgery, Jeonbuk National University Hospital, Jeonju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Goh+TS%22">Goh TS</searchLink>; Department of Orthopaedic Surgery, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Min+JH%22">Min JH</searchLink>; Department of Rehabilitation Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Stojkovic+T%22">Stojkovic T</searchLink>; Sorbonne Université, Service de Neuromyologie, Centre de référence Nord-Est-Ile-de-France, Institut de Myologie, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital 75651 Paris Cedex 13, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ackermann-Bonan+I%22">Ackermann-Bonan I</searchLink>; Sorbonne Université, Service de Neuromyologie, Centre de référence Nord-Est-Ile-de-France, Institut de Myologie, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital 75651 Paris Cedex 13, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jaiswal+JK%22">Jaiswal JK</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, 7144 13th Pl NW, Washington, DC, USA. jkjaiswal@cnmc.org.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. jkjaiswal@cnmc.org.
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  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 Oct; Vol. 18 (10), pp. 4034-4058. <i>Date of Electronic Publication: </i>2026 Oct 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
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