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MEDA-PKD: a dynamic, real-time analytics platform for precision care in autosomal dominant polycystic kidney disease.

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Title: MEDA-PKD: a dynamic, real-time analytics platform for precision care in autosomal dominant polycystic kidney disease.
Authors: Grundmann F; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany., Arjune S; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany., Alkarkoukly S; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute for Biomedical Informatics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Bartram MP; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany., Beck BB; Institute of Human Genetics, University of Cologne Faculty of Medicine and University Hospital Cologne, Würzburg, Germany., Benzing T; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany., Boehm V; Institute for Genetics, University of Cologne, Cologne, Germany., Bohl K; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Burst V; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.; Emergency Department, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Busch M; Department of Internal Medicine III, University Hospital Jena, Friedrich-Schiller-University, Jena, Germany., Cakiroglu F; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Cukoski S; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany., Gerke P; Nierenzentrum Lübeck, Lübeck, Germany., Große-Hokamp N; Institute for Diagnostic and Interventional Radiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Halbritter J; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Renal Division, Department of Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Matrisch L; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Persigehl T; Institute for Diagnostic and Interventional Radiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Petzold F; Division of Nephrology, Department of Endocrinology, Nephrology, and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Schmidt J; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.; Bonacci GmbH, Cologne, Germany., Schmitt R; Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.; Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany., Todorova P; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Center for Rare Diseases Düsseldorf, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Wanner C; Department of Clinical Studies and Epidemiology, Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany., Antczak P; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. philipp.antczak@uk-koeln.de.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. philipp.antczak@uk-koeln.de.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany. philipp.antczak@uk-koeln.de., Müller RU; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Center for Rare Diseases Düsseldorf, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.
Corporate Authors: AD(H)PKD Study Group
Source: NPJ digital medicine [NPJ Digit Med] 2026 Oct 20; Vol. 9 (1). Date of Electronic Publication: 2026 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101731738 Publication Model: Electronic Cited Medium: Internet ISSN: 2398-6352 (Electronic) Linking ISSN: 23986352 NLM ISO Abbreviation: NPJ Digit Med Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Grundmann+F%22">Grundmann F</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.<br /><searchLink fieldCode="AU" term="%22Arjune+S%22">Arjune S</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.<br /><searchLink fieldCode="AU" term="%22Alkarkoukly+S%22">Alkarkoukly S</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute for Biomedical Informatics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bartram+MP%22">Bartram MP</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.<br /><searchLink fieldCode="AU" term="%22Beck+BB%22">Beck BB</searchLink>; Institute of Human Genetics, University of Cologne Faculty of Medicine and University Hospital Cologne, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Benzing+T%22">Benzing T</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.<br /><searchLink fieldCode="AU" term="%22Boehm+V%22">Boehm V</searchLink>; Institute for Genetics, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bohl+K%22">Bohl K</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Burst+V%22">Burst V</searchLink>; 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Institute for Diagnostic and Interventional Radiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Petzold+F%22">Petzold F</searchLink>; Division of Nephrology, Department of Endocrinology, Nephrology, and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+J%22">Schmidt J</searchLink>; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.; Bonacci GmbH, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitt+R%22">Schmitt R</searchLink>; Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.; Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Todorova+P%22">Todorova P</searchLink>; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Center for Rare Diseases Düsseldorf, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Wanner+C%22">Wanner C</searchLink>; Department of Clinical Studies and Epidemiology, Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Antczak+P%22">Antczak P</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. philipp.antczak@uk-koeln.de.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. philipp.antczak@uk-koeln.de.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany. philipp.antczak@uk-koeln.de.<br /><searchLink fieldCode="AU" term="%22Müller+RU%22">Müller RU</searchLink>; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Düsseldorf, North Rhine-Westphalia, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.; Center for Rare Diseases Düsseldorf, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. roman-ulrich.mueller@med.uni-duesseldorf.de.
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