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A randomized Phase 1 study of telisotuzumab adizutecan (ABBV-400, Temab-A) in combination with bevacizumab versus trifluridine-tipiracil with bevacizumab in patients with metastatic colorectal cancer.

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Title: A randomized Phase 1 study of telisotuzumab adizutecan (ABBV-400, Temab-A) in combination with bevacizumab versus trifluridine-tipiracil with bevacizumab in patients with metastatic colorectal cancer.
Authors: Cecchini M; Department of Internal Medicine (Medical Oncology), Yale School of Medicine, New Haven, CT, USA. Electronic address: michael.cecchini@yale.edu., Cruz-Correa M; University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, and Pan-American Center for Oncology Trials, San Juan, Puerto Rico., Han SW; Department of Internal Medicine, Seoul National University Hospital and Seoul National University Cancer Research Institute, Seoul, Republic of Korea., Raghav K; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Landa-Magdalena A; Department of Medical Oncology, Cancer Center Clínica Universidad de Navarra, Pamplona, Spain., Strickler JH; Department of Medicine, Duke University, Durham, NC, USA., Calvo A; Gregorio Marañón University General Hospital, Madrid, Spain., Hollebecque A; Gustave Roussy, Villejuif, France., Nakajima TE; Kyoto University Graduate School of Medicine, Kyoto, Japan., Perl G; Thoracic Cancer Service, Davidoff Cancer Center, Beilinson, Petah Tikva, Israel., Jain V; Mater Hospital Brisbane, Queensland, Australia., Hunter Z; AbbVie Inc, North Chicago, IL, USA., Chan EM; AbbVie Inc, North Chicago, IL, USA., Blaney M; AbbVie Inc, North Chicago, IL, USA., Li R; AbbVie Inc, North Chicago, IL, USA., Vasilopoulos A; AbbVie Inc, North Chicago, IL, USA., Parikh A; AbbVie Inc, North Chicago, IL, USA., Sharma MR; START Center for Cancer Research - Midwest, Grand Rapids, MI, USA.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2026 Oct 24. Date of Electronic Publication: 2026 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A randomized Phase 1 study of telisotuzumab adizutecan (ABBV-400, Temab-A) in combination with bevacizumab versus trifluridine-tipiracil with bevacizumab in patients with metastatic colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Cecchini+M%22">Cecchini M</searchLink>; Department of Internal Medicine (Medical Oncology), Yale School of Medicine, New Haven, CT, USA. Electronic address: michael.cecchini@yale.edu.<br /><searchLink fieldCode="AU" term="%22Cruz-Correa+M%22">Cruz-Correa M</searchLink>; University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, and Pan-American Center for Oncology Trials, San Juan, Puerto Rico.<br /><searchLink fieldCode="AU" term="%22Han+SW%22">Han SW</searchLink>; Department of Internal Medicine, Seoul National University Hospital and Seoul National University Cancer Research Institute, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Raghav+K%22">Raghav K</searchLink>; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Landa-Magdalena+A%22">Landa-Magdalena A</searchLink>; Department of Medical Oncology, Cancer Center Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Strickler+JH%22">Strickler JH</searchLink>; Department of Medicine, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Calvo+A%22">Calvo A</searchLink>; Gregorio Marañón University General Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Hollebecque+A%22">Hollebecque A</searchLink>; Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Nakajima+TE%22">Nakajima TE</searchLink>; Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Perl+G%22">Perl G</searchLink>; Thoracic Cancer Service, Davidoff Cancer Center, Beilinson, Petah Tikva, Israel.<br /><searchLink fieldCode="AU" term="%22Jain+V%22">Jain V</searchLink>; Mater Hospital Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Hunter+Z%22">Hunter Z</searchLink>; AbbVie Inc, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chan+EM%22">Chan EM</searchLink>; AbbVie Inc, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Blaney+M%22">Blaney M</searchLink>; AbbVie Inc, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; AbbVie Inc, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Vasilopoulos+A%22">Vasilopoulos A</searchLink>; AbbVie Inc, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Parikh+A%22">Parikh A</searchLink>; AbbVie Inc, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+MR%22">Sharma MR</searchLink>; START Center for Cancer Research - Midwest, Grand Rapids, MI, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9007735 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1569-8041 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209237534%22">09237534 </searchLink><i>NLM ISO Abbreviation: </i>Ann Oncol <i>Subsets: </i>MEDLINE
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              Text: 2026 Oct 24
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