Medicinal Chemistry : A Molecular and Biochemical Approach
Saved in:
| Title: | Medicinal Chemistry : A Molecular and Biochemical Approach |
|---|---|
| Description: | Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level. |
| Authors: | Thomas Nogrady, Donald F. Weaver |
| Resource Type: | eBook. |
| Subjects: | Pharmaceutical chemistry, Chemistry, Pharmaceutical, Drug Design, Receptors, Drug |
| Categories: | MEDICAL / Pharmacology, MEDICAL / Toxicology, SCIENCE / Chemistry / General |
| Database: | eBook Collection (EBSCOhost) |
| FullText | Links: – Type: ebook-pdf – Type: ebook-epub Text: Availability: 0 |
|---|---|
| Header | DbId: nlebk DbLabel: eBook Collection (EBSCOhost) An: 143290 RelevancyScore: 998 AccessLevel: 6 PubType: eBook PubTypeId: ebook PreciseRelevancyScore: 998.4384765625 |
| IllustrationInfo | |
| ImageInfo | – Size: thumb Target: https://rps2images.ebscohost.com/rpsweb/othumb?id=NL$143290$PDF&s=r – Size: medium Target: https://rps2images.ebscohost.com/rpsweb/othumb?id=NL$143290$PDF&s=d |
| Items | – Name: Title Label: Title Group: Ti Data: Medicinal Chemistry : A Molecular and Biochemical Approach – Name: Abstract Label: Description Group: Ab Data: Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Thomas+Nogrady%22">Thomas Nogrady</searchLink><br /><searchLink fieldCode="AR" term="%22Donald+F%2E+Weaver%22">Donald F. Weaver</searchLink> – Name: TypePub Label: Resource Type Group: TypPub Data: eBook. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Pharmaceutical+chemistry%22">Pharmaceutical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Chemistry%2C+Pharmaceutical%22">Chemistry, Pharmaceutical</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+Design%22">Drug Design</searchLink><br /><searchLink fieldCode="DE" term="%22Receptors%2C+Drug%22">Receptors, Drug</searchLink> – Name: SubjectBISAC Label: Categories Group: Su Data: <searchLink fieldCode="ZK" term="%22MEDICAL+%2F+Pharmacology%22">MEDICAL / Pharmacology</searchLink><br /><searchLink fieldCode="ZK" term="%22MEDICAL+%2F+Toxicology%22">MEDICAL / Toxicology</searchLink><br /><searchLink fieldCode="ZK" term="%22SCIENCE+%2F+Chemistry+%2F+General%22">SCIENCE / Chemistry / General</searchLink> |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=nlebk&AN=143290 |
| RecordInfo | BibRecord: BibEntity: Classifications: – Code: 615.7 Scheme: ddc Type: prePub Languages: – Code: eng Text: English Subjects: – SubjectFull: Pharmaceutical chemistry Type: general – SubjectFull: Chemistry, Pharmaceutical Type: general – SubjectFull: Drug Design Type: general – SubjectFull: Receptors, Drug Type: general Titles: – TitleFull: Medicinal Chemistry : A Molecular and Biochemical Approach Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Thomas Nogrady – PersonEntity: Name: NameFull: Donald F. Weaver – PersonEntity: Name: NameFull: Thomas Nogrady – PersonEntity: Name: NameFull: Donald F. Weaver IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2005 – D: 04 M: 02 Type: profile Y: 2014 Identifiers: – Type: isbn-print Value: 9780195104554 – Type: isbn-print Value: 9780195104561 – Type: isbn-electronic Value: 9780198026457 – Type: isbn-electronic Value: 9780190282967 Titles: – TitleFull: Medicinal Chemistry : A Molecular and Biochemical Approach Type: main |
| ResultId | 1 |
