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Metallo-Drugs: Development and Action of Anticancer Agents

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Title: Metallo-Drugs: Development and Action of Anticancer Agents
Description: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic... not forgetting that it also provides excellent information for teaching.
Authors: Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel
Resource Type: eBook.
Subjects: Pharmaceutical chemistry, Cisplatin, Organoplatinum compounds--Therapeutic use, Antineoplastic agents
Categories: SCIENCE / Chemistry / Inorganic, MEDICAL / Chemotherapy, MEDICAL / Pharmacology, MEDICAL / Pharmacy, SCIENCE / Chemistry / Clinical, SCIENCE / Chemistry / Industrial & Technical, TECHNOLOGY & ENGINEERING / Pharmaceutical
Database: eBook Collection (EBSCOhost)
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PubType: eBook
PubTypeId: ebook
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  Data: Metallo-Drugs: Development and Action of Anticancer Agents
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  Data: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic... not forgetting that it also provides excellent information for teaching.
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  Data: <searchLink fieldCode="DE" term="%22Pharmaceutical+chemistry%22">Pharmaceutical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Cisplatin%22">Cisplatin</searchLink><br /><searchLink fieldCode="DE" term="%22Organoplatinum+compounds--Therapeutic+use%22">Organoplatinum compounds--Therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink>
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RecordInfo BibRecord:
  BibEntity:
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      – Code: 615.798
        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Pharmaceutical chemistry
        Type: general
      – SubjectFull: Cisplatin
        Type: general
      – SubjectFull: Organoplatinum compounds--Therapeutic use
        Type: general
      – SubjectFull: Antineoplastic agents
        Type: general
    Titles:
      – TitleFull: Metallo-Drugs: Development and Action of Anticancer Agents
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Astrid Sigel
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          Name:
            NameFull: Helmut Sigel
      – PersonEntity:
          Name:
            NameFull: Eva Freisinger
      – PersonEntity:
          Name:
            NameFull: Roland K.O. Sigel
      – PersonEntity:
          Name:
            NameFull: Astrid Sigel
      – PersonEntity:
          Name:
            NameFull: Helmut Sigel
      – PersonEntity:
          Name:
            NameFull: Eva Freisinger
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          Name:
            NameFull: Roland K.O. Sigel
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2018
            – D: 20
              M: 06
              Type: profile
              Y: 2018
          Identifiers:
            – Type: isbn-print
              Value: 9783110469844
            – Type: isbn-electronic
              Value: 9783110469905
            – Type: isbn-electronic
              Value: 9783110470734
            – Type: isbn-electronic
              Value: 9783110470741
          Numbering:
            – Type: volume
              Value: 00018
          Titles:
            – TitleFull: Metallo-Drugs: Development and Action of Anticancer Agents
              Type: main
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