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Network Medicine : Complex Systems in Human Disease and Therapeutics

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Title: Network Medicine : Complex Systems in Human Disease and Therapeutics
Description: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine's unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.
Authors: Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman
Resource Type: eBook.
Subjects: Medicine--Data processing, Therapeutics--Data processing, Medical informatics, Data integration (Computer science), Diseases--Causes and theories of causation--Data processing
Categories: MEDICAL / Research, MEDICAL / Diagnosis, MEDICAL / Diseases
Database: eBook Collection (EBSCOhost)
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  Data: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine's unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.
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        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Medicine--Data processing
        Type: general
      – SubjectFull: Therapeutics--Data processing
        Type: general
      – SubjectFull: Medical informatics
        Type: general
      – SubjectFull: Data integration (Computer science)
        Type: general
      – SubjectFull: Diseases--Causes and theories of causation--Data processing
        Type: general
    Titles:
      – TitleFull: Network Medicine : Complex Systems in Human Disease and Therapeutics
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          Name:
            NameFull: Joseph Loscalzo
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            NameFull: Albert-László Barabási
      – PersonEntity:
          Name:
            NameFull: Edwin K. Silverman
      – PersonEntity:
          Name:
            NameFull: Joseph Loscalzo
      – PersonEntity:
          Name:
            NameFull: Albert-László Barabási
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2017
            – D: 08
              M: 02
              Type: profile
              Y: 2019
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              Value: 9780674436534
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              Value: 9780674545533
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              Value: 9780674545526
          Titles:
            – TitleFull: Network Medicine : Complex Systems in Human Disease and Therapeutics
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