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Bone Marrow Transplantation Across Major Genetic Barriers

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Title: Bone Marrow Transplantation Across Major Genetic Barriers
Description: The importance of bone marrow transplantation for patients who do not have a matched sibling donor cannot be overestimated. This subject has always been in the public domain, accentuated by dramatic appeals, from time to time, to search for matched volunteer donors in the public at large. Unfortunately, the availability of such donors is limited, due to the remarkable genetic diversity of humans. Thus, although registries of such volunteers now include more than eight million individuals, we still face the problem of finding a matched donor for about 30% of patients in need. To address this burning issue, extensive clinical and basic research is performed in leading institutes around the world.This book presents updated accounts of the different aspects of this research. The scope of the book is very wide, including strategies to overcome graft vs. host (GVH) disease and graft rejection, cell therapy to prevent leukemia relapse, and a range of modalities to improve immune reconstitution after transplantation. In addition, new approaches to induce immune tolerance towards organ transplants by means of hematopoietic stem cell transplantation are extensively reviewed.
Authors: Yair Reisner, Massimo Fabrizio Martelli, Robertson Parkman
Resource Type: eBook.
Subjects: Graft rejection--Prevention, Human immunogenetics, Human genetics--Variation, Bone marrow--Transplantation, Hematopoietic stem cells, Graft versus host disease--Prevention
Categories: MEDICAL / Immunology, MEDICAL / Hematology, MEDICAL / Oncology / General
Database: eBook Collection (EBSCOhost)
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  – Type: ebook-pdf
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Header DbId: nlebk
DbLabel: eBook Collection (EBSCOhost)
An: 374894
RelevancyScore: 1031
AccessLevel: 6
PubType: eBook
PubTypeId: ebook
PreciseRelevancyScore: 1031.17456054688
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  Data: Bone Marrow Transplantation Across Major Genetic Barriers
– Name: Abstract
  Label: Description
  Group: Ab
  Data: The importance of bone marrow transplantation for patients who do not have a matched sibling donor cannot be overestimated. This subject has always been in the public domain, accentuated by dramatic appeals, from time to time, to search for matched volunteer donors in the public at large. Unfortunately, the availability of such donors is limited, due to the remarkable genetic diversity of humans. Thus, although registries of such volunteers now include more than eight million individuals, we still face the problem of finding a matched donor for about 30% of patients in need. To address this burning issue, extensive clinical and basic research is performed in leading institutes around the world.This book presents updated accounts of the different aspects of this research. The scope of the book is very wide, including strategies to overcome graft vs. host (GVH) disease and graft rejection, cell therapy to prevent leukemia relapse, and a range of modalities to improve immune reconstitution after transplantation. In addition, new approaches to induce immune tolerance towards organ transplants by means of hematopoietic stem cell transplantation are extensively reviewed.
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  Data: <searchLink fieldCode="AR" term="%22Yair+Reisner%22">Yair Reisner</searchLink><br /><searchLink fieldCode="AR" term="%22Massimo+Fabrizio+Martelli%22">Massimo Fabrizio Martelli</searchLink><br /><searchLink fieldCode="AR" term="%22Robertson+Parkman%22">Robertson Parkman</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Graft+rejection--Prevention%22">Graft rejection--Prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Human+immunogenetics%22">Human immunogenetics</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genetics--Variation%22">Human genetics--Variation</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+marrow--Transplantation%22">Bone marrow--Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Hematopoietic+stem+cells%22">Hematopoietic stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+versus+host+disease--Prevention%22">Graft versus host disease--Prevention</searchLink>
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  Data: <searchLink fieldCode="ZK" term="%22MEDICAL+%2F+Immunology%22">MEDICAL / Immunology</searchLink><br /><searchLink fieldCode="ZK" term="%22MEDICAL+%2F+Hematology%22">MEDICAL / Hematology</searchLink><br /><searchLink fieldCode="ZK" term="%22MEDICAL+%2F+Oncology+%2F+General%22">MEDICAL / Oncology / General</searchLink>
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RecordInfo BibRecord:
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      – Code: 617.4410592
        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Graft rejection--Prevention
        Type: general
      – SubjectFull: Human immunogenetics
        Type: general
      – SubjectFull: Human genetics--Variation
        Type: general
      – SubjectFull: Bone marrow--Transplantation
        Type: general
      – SubjectFull: Hematopoietic stem cells
        Type: general
      – SubjectFull: Graft versus host disease--Prevention
        Type: general
    Titles:
      – TitleFull: Bone Marrow Transplantation Across Major Genetic Barriers
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Yair Reisner
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          Name:
            NameFull: Massimo Fabrizio Martelli
      – PersonEntity:
          Name:
            NameFull: Robertson Parkman
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            NameFull: Yair Reisner
      – PersonEntity:
          Name:
            NameFull: Massimo Fabrizio Martelli
      – PersonEntity:
          Name:
            NameFull: Robertson Parkman
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2010
            – D: 04
              M: 02
              Type: profile
              Y: 2014
          Identifiers:
            – Type: isbn-print
              Value: 9789814271264
            – Type: isbn-electronic
              Value: 9789814271271
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            – TitleFull: Bone Marrow Transplantation Across Major Genetic Barriers
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