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Quorum Quenching : A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development

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Title: Quorum Quenching : A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
Description: Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand. One potential target for new therapeutics is inhibition of quorum sensing: how microorganisms communicate and form biofilms in a density-dependent manner. Inhibiting this system via ‘quorum quenching'(QQ) is a promising route to new pharmaceuticals and for controlling biofilm formation and growth. Quorum sensing also provides interesting possibilities in synthetic biology for producing novel products, biosensors, bioactive molecules, and so on. This book covers the biology of quorum sensing and quenching, and potential sources of QQ enzymes and other inhibitors, as well as an overview of their mechanism and potential biotech applications. The book also covers the potential for new drug development from QQ, covering a range of related topics including protein engineering, imaging and computational studies, and integrated systems. This book is an ideal companion to researchers in chemical biology and medicinal chemistry, particularly those interested in biofilm formation, quorum sensing, novel antimicrobial development, synthetic biology and enzymology.
Authors: Naga Raju Maddela, Ranjit Pabbati, Venkateswar Reddy Kondakindi
Resource Type: eBook.
Subjects: Drug development, Quorum sensing (Microbiology), Drug resistance in microorganisms
Categories: SCIENCE / Life Sciences / Bacteriology, SCIENCE / Life Sciences / Biochemistry, SCIENCE / Chemistry / Organic
Database: eBook Collection (EBSCOhost)
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  – Type: ebook-epub
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Header DbId: nlebk
DbLabel: eBook Collection (EBSCOhost)
An: 3761620
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PubType: eBook
PubTypeId: ebook
PreciseRelevancyScore: 1122.83581542969
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  Data: Quorum Quenching : A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand. One potential target for new therapeutics is inhibition of quorum sensing: how microorganisms communicate and form biofilms in a density-dependent manner. Inhibiting this system via ‘quorum quenching'(QQ) is a promising route to new pharmaceuticals and for controlling biofilm formation and growth. Quorum sensing also provides interesting possibilities in synthetic biology for producing novel products, biosensors, bioactive molecules, and so on. This book covers the biology of quorum sensing and quenching, and potential sources of QQ enzymes and other inhibitors, as well as an overview of their mechanism and potential biotech applications. The book also covers the potential for new drug development from QQ, covering a range of related topics including protein engineering, imaging and computational studies, and integrated systems. This book is an ideal companion to researchers in chemical biology and medicinal chemistry, particularly those interested in biofilm formation, quorum sensing, novel antimicrobial development, synthetic biology and enzymology.
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  Data: <searchLink fieldCode="AR" term="%22Naga+Raju+Maddela%22">Naga Raju Maddela</searchLink><br /><searchLink fieldCode="AR" term="%22Ranjit+Pabbati%22">Ranjit Pabbati</searchLink><br /><searchLink fieldCode="AR" term="%22Venkateswar+Reddy+Kondakindi%22">Venkateswar Reddy Kondakindi</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Drug+development%22">Drug development</searchLink><br /><searchLink fieldCode="DE" term="%22Quorum+sensing+%28Microbiology%29%22">Quorum sensing (Microbiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance+in+microorganisms%22">Drug resistance in microorganisms</searchLink>
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  Data: <searchLink fieldCode="ZK" term="%22SCIENCE+%2F+Life+Sciences+%2F+Bacteriology%22">SCIENCE / Life Sciences / Bacteriology</searchLink><br /><searchLink fieldCode="ZK" term="%22SCIENCE+%2F+Life+Sciences+%2F+Biochemistry%22">SCIENCE / Life Sciences / Biochemistry</searchLink><br /><searchLink fieldCode="ZK" term="%22SCIENCE+%2F+Chemistry+%2F+Organic%22">SCIENCE / Chemistry / Organic</searchLink>
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RecordInfo BibRecord:
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    Classifications:
      – Code: 571.74
        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Drug development
        Type: general
      – SubjectFull: Quorum sensing (Microbiology)
        Type: general
      – SubjectFull: Drug resistance in microorganisms
        Type: general
    Titles:
      – TitleFull: Quorum Quenching : A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
        Type: main
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    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Naga Raju Maddela
      – PersonEntity:
          Name:
            NameFull: Ranjit Pabbati
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            NameFull: Venkateswar Reddy Kondakindi
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          Name:
            NameFull: Naga Raju Maddela
      – PersonEntity:
          Name:
            NameFull: Ranjit Pabbati
      – PersonEntity:
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            NameFull: Venkateswar Reddy Kondakindi
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2024
            – D: 10
              M: 01
              Type: profile
              Y: 2024
          Identifiers:
            – Type: isbn-print
              Value: 9781839167614
            – Type: isbn-electronic
              Value: 9781837671397
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            – Type: volume
              Value: 00022
          Titles:
            – TitleFull: Quorum Quenching : A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
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