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Codon Evolution : Mechanisms and Models

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Title: Codon Evolution : Mechanisms and Models
Description: Codon-based models of evolution are a relatively new addition to the toolkit of computational biologists, and in recent years remarkable progress has been made in this area. The study of evolution at the codon level captures information contained in both amino acid and synonymous DNA substitutions. By combining these two types of information, codon analyses are more powerful than those of either amino acid or DNA evolution alone. This is a clear benefit for most evolutionary analyses, including phylogenetic reconstruction, detection of selection, ancestral sequence reconstruction, and alignment of coding DNA. Despite the theoretical advantages of codon based models, their relative complexity delayed their widespread use. Only in recent years, when large-scale sequencing projects produced sufficient genomic data and computational power increased, did their usage become more common. In Codon Evolution, leading researchers in the field of molecular evolution provide the latest insights from codon-based analyses of genetic sequences. The first part of the book provides comprehensive coverage of the developments of various types of codon substitution models such as parametric and empirical models used in maximum likelihood as well as Bayesian frameworks. Subsequent chapters examine the use of codon models to infer selection and other applications of codon models to biological systems. The second part of the book focuses on codon usage bias. Both the underlying mechanisms as well as current methods to analyse codon usage bias are presented.
Authors: Gina M. Cannarozzi, Adrian Schneider
Resource Type: eBook.
Subjects: Evolutionary genetics--Mathematical models, Evolutionary genetics--Computer simulation, Molecular evolution--Mathematical models, Molecular evolution--Computer simulation
Categories: SCIENCE / Life Sciences / Evolution
Database: eBook Collection (EBSCOhost)
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Header DbId: nlebk
DbLabel: eBook Collection (EBSCOhost)
An: 437290
RelevancyScore: 1044
AccessLevel: 6
PubType: eBook
PubTypeId: ebook
PreciseRelevancyScore: 1044.26904296875
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  Data: Codon Evolution : Mechanisms and Models
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  Data: Codon-based models of evolution are a relatively new addition to the toolkit of computational biologists, and in recent years remarkable progress has been made in this area. The study of evolution at the codon level captures information contained in both amino acid and synonymous DNA substitutions. By combining these two types of information, codon analyses are more powerful than those of either amino acid or DNA evolution alone. This is a clear benefit for most evolutionary analyses, including phylogenetic reconstruction, detection of selection, ancestral sequence reconstruction, and alignment of coding DNA. Despite the theoretical advantages of codon based models, their relative complexity delayed their widespread use. Only in recent years, when large-scale sequencing projects produced sufficient genomic data and computational power increased, did their usage become more common. In Codon Evolution, leading researchers in the field of molecular evolution provide the latest insights from codon-based analyses of genetic sequences. The first part of the book provides comprehensive coverage of the developments of various types of codon substitution models such as parametric and empirical models used in maximum likelihood as well as Bayesian frameworks. Subsequent chapters examine the use of codon models to infer selection and other applications of codon models to biological systems. The second part of the book focuses on codon usage bias. Both the underlying mechanisms as well as current methods to analyse codon usage bias are presented.
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  Data: <searchLink fieldCode="AR" term="%22Gina+M%2E+Cannarozzi%22">Gina M. Cannarozzi</searchLink><br /><searchLink fieldCode="AR" term="%22Adrian+Schneider%22">Adrian Schneider</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Evolutionary+genetics--Mathematical+models%22">Evolutionary genetics--Mathematical models</searchLink><br /><searchLink fieldCode="DE" term="%22Evolutionary+genetics--Computer+simulation%22">Evolutionary genetics--Computer simulation</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+evolution--Mathematical+models%22">Molecular evolution--Mathematical models</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+evolution--Computer+simulation%22">Molecular evolution--Computer simulation</searchLink>
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      – Code: 572.86
        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Evolutionary genetics--Mathematical models
        Type: general
      – SubjectFull: Evolutionary genetics--Computer simulation
        Type: general
      – SubjectFull: Molecular evolution--Mathematical models
        Type: general
      – SubjectFull: Molecular evolution--Computer simulation
        Type: general
    Titles:
      – TitleFull: Codon Evolution : Mechanisms and Models
        Type: main
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            NameFull: Gina M. Cannarozzi
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            NameFull: Adrian Schneider
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2012
            – D: 04
              M: 02
              Type: profile
              Y: 2014
          Identifiers:
            – Type: isbn-print
              Value: 9780199601165
            – Type: isbn-electronic
              Value: 9780191624179
          Titles:
            – TitleFull: Codon Evolution : Mechanisms and Models
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