View in EDS PDF Full Text

Consanguinity, Inbreeding, and Genetic Drift in Italy

Saved in:
Bibliographic Details
Title: Consanguinity, Inbreeding, and Genetic Drift in Italy
Description: In 1951, the geneticist Luigi Luca Cavalli-Sforza was teaching in Parma when a student--a priest named Antonio Moroni--told him about rich church records of demography and marriages between relatives. After convincing the Church to open its records, Cavalli-Sforza, Moroni, and Gianna Zei embarked on a landmark study that would last fifty years and cover all of Italy. This book assembles and analyzes the team's research for the first time. Using blood testing as well as church records, the team investigated the frequency of consanguineous marriages and its use for estimating inbreeding and studying the relations between inbreeding and drift. They tested the importance of random genetic drift by studying population structure through demography of the last three centuries, using it to predict the spatial variation of frequencies of genetic markers. The authors find that drift-related genetic variation, including its stabilization by migration, is best predicted by computer simulation. They also analyze the usefulness and limits of the concept of deme for defining Mendelian populations. The genetic effect of consanguineous marriage on recessive genetic diseases and for the detection of dominance in metric characters are also studied. Ultimately bringing together the many strands of their massive project, Cavalli-Sforza, Moroni, and Zei are able to map genetic drift in all of Italy's approximately 8,000 communes and to demonstrate the relationship between each locality's drift and various ecological and demographic factors. In terms of both methods and findings, their accomplishment is tremendously important for understanding human social structure and the genetic effects of drift and inbreeding.
Authors: L L Cavalli-sforza, Antonio Moroni, Gianna Zei
Resource Type: eBook.
Subjects: Human genetics--Variation, Population genetics, Human population genetics--Italy, Conganguinity--Italy, Inbreeding--Italy, Consanguinity
Categories: SCIENCE / Life Sciences / Biology
Database: eBook Collection (EBSCOhost)
FullText Links:
  – Type: ebook-pdf
Text:
  Availability: 0
Header DbId: nlebk
DbLabel: eBook Collection (EBSCOhost)
An: 529487
RelevancyScore: 992
AccessLevel: 6
PubType: eBook
PubTypeId: ebook
PreciseRelevancyScore: 991.891296386719
IllustrationInfo
ImageInfo – Size: thumb
  Target: https://rps2images.ebscohost.com/rpsweb/othumb?id=NL$529487$PDF&s=r
– Size: medium
  Target: https://rps2images.ebscohost.com/rpsweb/othumb?id=NL$529487$PDF&s=d
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Consanguinity, Inbreeding, and Genetic Drift in Italy
– Name: Abstract
  Label: Description
  Group: Ab
  Data: In 1951, the geneticist Luigi Luca Cavalli-Sforza was teaching in Parma when a student--a priest named Antonio Moroni--told him about rich church records of demography and marriages between relatives. After convincing the Church to open its records, Cavalli-Sforza, Moroni, and Gianna Zei embarked on a landmark study that would last fifty years and cover all of Italy. This book assembles and analyzes the team's research for the first time. Using blood testing as well as church records, the team investigated the frequency of consanguineous marriages and its use for estimating inbreeding and studying the relations between inbreeding and drift. They tested the importance of random genetic drift by studying population structure through demography of the last three centuries, using it to predict the spatial variation of frequencies of genetic markers. The authors find that drift-related genetic variation, including its stabilization by migration, is best predicted by computer simulation. They also analyze the usefulness and limits of the concept of deme for defining Mendelian populations. The genetic effect of consanguineous marriage on recessive genetic diseases and for the detection of dominance in metric characters are also studied. Ultimately bringing together the many strands of their massive project, Cavalli-Sforza, Moroni, and Zei are able to map genetic drift in all of Italy's approximately 8,000 communes and to demonstrate the relationship between each locality's drift and various ecological and demographic factors. In terms of both methods and findings, their accomplishment is tremendously important for understanding human social structure and the genetic effects of drift and inbreeding.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22L+L+Cavalli-sforza%22">L L Cavalli-sforza</searchLink><br /><searchLink fieldCode="AR" term="%22Antonio+Moroni%22">Antonio Moroni</searchLink><br /><searchLink fieldCode="AR" term="%22Gianna+Zei%22">Gianna Zei</searchLink>
– Name: TypePub
  Label: Resource Type
  Group: TypPub
  Data: eBook.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Human+genetics--Variation%22">Human genetics--Variation</searchLink><br /><searchLink fieldCode="DE" term="%22Population+genetics%22">Population genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Human+population+genetics--Italy%22">Human population genetics--Italy</searchLink><br /><searchLink fieldCode="DE" term="%22Conganguinity--Italy%22">Conganguinity--Italy</searchLink><br /><searchLink fieldCode="DE" term="%22Inbreeding--Italy%22">Inbreeding--Italy</searchLink><br /><searchLink fieldCode="DE" term="%22Consanguinity%22">Consanguinity</searchLink>
– Name: SubjectBISAC
  Label: Categories
  Group: Su
  Data: <searchLink fieldCode="ZK" term="%22SCIENCE+%2F+Life+Sciences+%2F+Biology%22">SCIENCE / Life Sciences / Biology</searchLink>
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=nlebk&AN=529487
RecordInfo BibRecord:
  BibEntity:
    Classifications:
      – Code: 304.60945
        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Human genetics--Variation
        Type: general
      – SubjectFull: Population genetics
        Type: general
      – SubjectFull: Human population genetics--Italy
        Type: general
      – SubjectFull: Conganguinity--Italy
        Type: general
      – SubjectFull: Inbreeding--Italy
        Type: general
      – SubjectFull: Consanguinity
        Type: general
    Titles:
      – TitleFull: Consanguinity, Inbreeding, and Genetic Drift in Italy
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: L L Cavalli-sforza
      – PersonEntity:
          Name:
            NameFull: Antonio Moroni
      – PersonEntity:
          Name:
            NameFull: Gianna Zei
      – PersonEntity:
          Name:
            NameFull: L L Cavalli-sforza
      – PersonEntity:
          Name:
            NameFull: Antonio Moroni
      – PersonEntity:
          Name:
            NameFull: Gianna Zei
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2004
            – D: 04
              M: 02
              Type: profile
              Y: 2014
          Identifiers:
            – Type: isbn-print
              Value: 9780691089928
            – Type: isbn-print
              Value: 9780691089911
            – Type: isbn-electronic
              Value: 9781400847273
          Numbering:
            – Type: volume
              Value: 00039
          Titles:
            – TitleFull: Consanguinity, Inbreeding, and Genetic Drift in Italy
              Type: main
ResultId 1