Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications
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| Title: | Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications |
|---|---|
| Description: | In recent years, thousands of cancer biomarkers have been discovered and described in scientific literature. The promise of personalized medicine, where diseases such as cancer are accurately diagnosed and treatments tailored specifically for individuals, is becoming a reality. Significant advances in biomarker-based research methodologies such as Next Generation Sequencing (NGS) are at the cusp of ushering in a new era of personal medicine. However, unlike the spectacular advances in research technologies for disease biomarker discovery, biomarker-based technologies that can effectively be used in the clinic (or point-of-care) to enable personalized medicine are still lacking. In this book, we feature a selection of emerging technologies which are aimed at enabling clinical applications of personalised medicine. Each of the eight chapters is written by a leading group at the intersection of microfluidics, biology, and nanotechnology. For instance, to accelerate a major bottleneck in the development of clinically useful protein diagnostics, we discuss the application of yeast-derived single chain Fragment variable (scFv) antibody-like molecules as a potential low cost alternative to traditional antibody-based diagnostics. Circulating tumour cells (CTCs) are an emerging class of cancer biomarkers and a potential resource for understanding cancer progression; we explore various strategies combining microfluidics with nanotechnology for capturing CTCs. The book includes an evaluation of some current and emerging technologies for detecting clinical DNA methylation, another potential cancer biomarker. As personalized medicine may involve tracking a patient's response to treatment, the application of microfluidics to detect metabolites in biological fluids is also discussed. Finally, the ultimate goal of personalized medicine is targeted therapy. One promising approach is RNAi technology which uses short nucleotides to disrupt cancer pathways. In this book, nanoparticle approaches to deliver these short nucleotides are discussed. |
| Authors: | Shiddiky, Muhammad J. A. |
| Resource Type: | eBook. |
| Subjects: | Microfluidics, Nanotechnology |
| Categories: | TECHNOLOGY & ENGINEERING / Reference, TECHNOLOGY & ENGINEERING / Engineering (General) |
| Database: | eBook Collection (EBSCOhost) |
| FullText | Links: – Type: ebook-pdf Text: Availability: 0 |
|---|---|
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| Items | – Name: Title Label: Title Group: Ti Data: Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications – Name: Abstract Label: Description Group: Ab Data: In recent years, thousands of cancer biomarkers have been discovered and described in scientific literature. The promise of personalized medicine, where diseases such as cancer are accurately diagnosed and treatments tailored specifically for individuals, is becoming a reality. Significant advances in biomarker-based research methodologies such as Next Generation Sequencing (NGS) are at the cusp of ushering in a new era of personal medicine. However, unlike the spectacular advances in research technologies for disease biomarker discovery, biomarker-based technologies that can effectively be used in the clinic (or point-of-care) to enable personalized medicine are still lacking. In this book, we feature a selection of emerging technologies which are aimed at enabling clinical applications of personalised medicine. Each of the eight chapters is written by a leading group at the intersection of microfluidics, biology, and nanotechnology. For instance, to accelerate a major bottleneck in the development of clinically useful protein diagnostics, we discuss the application of yeast-derived single chain Fragment variable (scFv) antibody-like molecules as a potential low cost alternative to traditional antibody-based diagnostics. Circulating tumour cells (CTCs) are an emerging class of cancer biomarkers and a potential resource for understanding cancer progression; we explore various strategies combining microfluidics with nanotechnology for capturing CTCs. The book includes an evaluation of some current and emerging technologies for detecting clinical DNA methylation, another potential cancer biomarker. As personalized medicine may involve tracking a patient's response to treatment, the application of microfluidics to detect metabolites in biological fluids is also discussed. Finally, the ultimate goal of personalized medicine is targeted therapy. One promising approach is RNAi technology which uses short nucleotides to disrupt cancer pathways. In this book, nanoparticle approaches to deliver these short nucleotides are discussed. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shiddiky%2C+Muhammad+J%2E+A%2E%22">Shiddiky, Muhammad J. A.</searchLink> – Name: TypePub Label: Resource Type Group: TypPub Data: eBook. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Microfluidics%22">Microfluidics</searchLink><br /><searchLink fieldCode="DE" term="%22Nanotechnology%22">Nanotechnology</searchLink> – Name: SubjectBISAC Label: Categories Group: Su Data: <searchLink fieldCode="ZK" term="%22TECHNOLOGY+%26+ENGINEERING+%2F+Reference%22">TECHNOLOGY & ENGINEERING / Reference</searchLink><br /><searchLink fieldCode="ZK" term="%22TECHNOLOGY+%26+ENGINEERING+%2F+Engineering+%28General%29%22">TECHNOLOGY & ENGINEERING / Engineering (General)</searchLink> |
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| RecordInfo | BibRecord: BibEntity: Classifications: – Code: 620.106 Scheme: ddc Type: prePub Languages: – Code: eng Text: English Subjects: – SubjectFull: Microfluidics Type: general – SubjectFull: Nanotechnology Type: general Titles: – TitleFull: Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shiddiky, Muhammad J. A. – PersonEntity: Name: NameFull: Shiddiky, Muhammad J. A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2013 – D: 04 M: 02 Type: profile Y: 2014 Identifiers: – Type: isbn-print Value: 9781628080209 – Type: isbn-electronic Value: 9781628080391 Titles: – TitleFull: Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications Type: main |
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