MICROSTRUCTURAL BRAIN ABNORMALITIES AND SYMPTOM DIMENSIONS IN CHILD AND ADOLESCENT PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER: A DIFFUSION TENSOR IMAGING STUDY.
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| Title: | MICROSTRUCTURAL BRAIN ABNORMALITIES AND SYMPTOM DIMENSIONS IN CHILD AND ADOLESCENT PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER: A DIFFUSION TENSOR IMAGING STUDY. |
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| Authors: | Lázaro, Luisa, Calvo, Anna, Ortiz, Ana G., Ortiz, Ana E., Morer, Astrid, Moreno, Elena, Calvo, Rosa, Bargallo, Núria |
| Source: | Depression & Anxiety (1091-4269). Dec2014, Vol. 31 Issue 12, p1007-1017. 11p. |
| Subjects: | Obsessive-compulsive disorder in adolescence, Obsessive-compulsive disorder in children, Brain abnormalities, Symptoms, Diffusion tensor imaging, Microstructure, White matter (Nerve tissue) |
| Abstract: | Background The aims of this study were to determine white matter (WM) microstructure abnormalities in obsessive-compulsive disorder (OCD) using diffusion tensor imaging, and to investigate whether these abnormalities differ according to OCD symptom dimensions. Methods Sixty-three child and adolescent OCD patients (11-18 years old) and 37 healthy subjects matched for gender, age, and estimated intelligence quotient were assessed by means of psychopathology scales and diffusion tensor magnetic resonance imaging. Results Compared with healthy controls OCD patients showed a significant decrease ( t = 3.79, P = .049 FDR-corrected) in fractional anisotropy (FA) in the anterior region of the corpus callosum (CC). In addition, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were significantly increased in OCD compared with controls in the CC and in several WM regions of the cingulate, frontal and occipital lobes, basal ganglia, cerebellum, and pons. Compared with healthy controls, OCD patients presenting the harm/checking dimension showed decreased FA in the CC and in the left anterior cingulate gyrus and caudate nucleus, whereas patients with a predominant contamination/washing symptom dimension presented significantly decreased FA in the left midbrain, lentiform nucleus, insula, and thalamus, and increased MD, AD, and RD in both the anterior lobes of cerebellum and in the pons. Conclusions The findings suggest WM abnormalities at the microstructural level in the pathogenesis of OCD. Moreover, WM abnormalities in OCD may vary according to the specific OCD symptom dimensions, thus indicating the clinical heterogeneity of the condition. [ABSTRACT FROM AUTHOR] |
| Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 100101342 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: MICROSTRUCTURAL BRAIN ABNORMALITIES AND SYMPTOM DIMENSIONS IN CHILD AND ADOLESCENT PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER: A DIFFUSION TENSOR IMAGING STUDY. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lázaro%2C+Luisa%22">Lázaro, Luisa</searchLink><br /><searchLink fieldCode="AR" term="%22Calvo%2C+Anna%22">Calvo, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Ortiz%2C+Ana+G%2E%22">Ortiz, Ana G.</searchLink><br /><searchLink fieldCode="AR" term="%22Ortiz%2C+Ana+E%2E%22">Ortiz, Ana E.</searchLink><br /><searchLink fieldCode="AR" term="%22Morer%2C+Astrid%22">Morer, Astrid</searchLink><br /><searchLink fieldCode="AR" term="%22Moreno%2C+Elena%22">Moreno, Elena</searchLink><br /><searchLink fieldCode="AR" term="%22Calvo%2C+Rosa%22">Calvo, Rosa</searchLink><br /><searchLink fieldCode="AR" term="%22Bargallo%2C+Núria%22">Bargallo, Núria</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. Dec2014, Vol. 31 Issue 12, p1007-1017. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder+in+adolescence%22">Obsessive-compulsive disorder in adolescence</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder+in+children%22">Obsessive-compulsive disorder in children</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+abnormalities%22">Brain abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Microstructure%22">Microstructure</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background The aims of this study were to determine white matter (WM) microstructure abnormalities in obsessive-compulsive disorder (OCD) using diffusion tensor imaging, and to investigate whether these abnormalities differ according to OCD symptom dimensions. Methods Sixty-three child and adolescent OCD patients (11-18 years old) and 37 healthy subjects matched for gender, age, and estimated intelligence quotient were assessed by means of psychopathology scales and diffusion tensor magnetic resonance imaging. Results Compared with healthy controls OCD patients showed a significant decrease ( t = 3.79, P = .049 FDR-corrected) in fractional anisotropy (FA) in the anterior region of the corpus callosum (CC). In addition, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were significantly increased in OCD compared with controls in the CC and in several WM regions of the cingulate, frontal and occipital lobes, basal ganglia, cerebellum, and pons. Compared with healthy controls, OCD patients presenting the harm/checking dimension showed decreased FA in the CC and in the left anterior cingulate gyrus and caudate nucleus, whereas patients with a predominant contamination/washing symptom dimension presented significantly decreased FA in the left midbrain, lentiform nucleus, insula, and thalamus, and increased MD, AD, and RD in both the anterior lobes of cerebellum and in the pons. Conclusions The findings suggest WM abnormalities at the microstructural level in the pathogenesis of OCD. Moreover, WM abnormalities in OCD may vary according to the specific OCD symptom dimensions, thus indicating the clinical heterogeneity of the condition. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/da.22330 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1007 Subjects: – SubjectFull: Obsessive-compulsive disorder in adolescence Type: general – SubjectFull: Obsessive-compulsive disorder in children Type: general – SubjectFull: Brain abnormalities Type: general – SubjectFull: Symptoms Type: general – SubjectFull: Diffusion tensor imaging Type: general – SubjectFull: Microstructure Type: general – SubjectFull: White matter (Nerve tissue) Type: general Titles: – TitleFull: MICROSTRUCTURAL BRAIN ABNORMALITIES AND SYMPTOM DIMENSIONS IN CHILD AND ADOLESCENT PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER: A DIFFUSION TENSOR IMAGING STUDY. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lázaro, Luisa – PersonEntity: Name: NameFull: Calvo, Anna – PersonEntity: Name: NameFull: Ortiz, Ana G. – PersonEntity: Name: NameFull: Ortiz, Ana E. – PersonEntity: Name: NameFull: Morer, Astrid – PersonEntity: Name: NameFull: Moreno, Elena – PersonEntity: Name: NameFull: Calvo, Rosa – PersonEntity: Name: NameFull: Bargallo, Núria IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 10914269 Numbering: – Type: volume Value: 31 – Type: issue Value: 12 Titles: – TitleFull: Depression & Anxiety (1091-4269) Type: main |
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