Glial ankyrins facilitate paranodal axoglial junction assembly.
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| Title: | Glial ankyrins facilitate paranodal axoglial junction assembly. |
|---|---|
| Authors: | Chang, Kae-Jiun, Zollinger, Daniel R, Susuki, Keiichiro, Sherman, Diane L, Makara, Michael A, Brophy, Peter J, Cooper, Edward C, Bennett, Vann, Mohler, Peter J, Rasband, Matthew N |
| Source: | Nature Neuroscience. Dec2014, Vol. 17 Issue 12, p1673-1681. 9p. |
| Subjects: | Ankyrins, Glial fibrillary acidic protein, Neurons, Nervous system, Neurosciences |
| Abstract: | Neuron-glia interactions establish functional membrane domains along myelinated axons. These include nodes of Ranvier, paranodal axoglial junctions and juxtaparanodes. Paranodal junctions are the largest vertebrate junctional adhesion complex, and they are essential for rapid saltatory conduction and contribute to assembly and maintenance of nodes. However, the molecular mechanisms underlying paranodal junction assembly are poorly understood. Ankyrins are cytoskeletal scaffolds traditionally associated with Na+ channel clustering in neurons and are important for membrane domain establishment and maintenance in many cell types. Here we show that ankyrin-B, expressed by Schwann cells, and ankyrin-G, expressed by oligodendrocytes, are highly enriched at the glial side of paranodal junctions where they interact with the essential glial junctional component neurofascin 155. Conditional knockout of ankyrins in oligodendrocytes disrupts paranodal junction assembly and delays nerve conduction during early development in mice. Thus, glial ankyrins function as major scaffolds that facilitate early and efficient paranodal junction assembly in the developing CNS. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 100160765 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Glial ankyrins facilitate paranodal axoglial junction assembly. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chang%2C+Kae-Jiun%22">Chang, Kae-Jiun</searchLink><br /><searchLink fieldCode="AR" term="%22Zollinger%2C+Daniel+R%22">Zollinger, Daniel R</searchLink><br /><searchLink fieldCode="AR" term="%22Susuki%2C+Keiichiro%22">Susuki, Keiichiro</searchLink><br /><searchLink fieldCode="AR" term="%22Sherman%2C+Diane+L%22">Sherman, Diane L</searchLink><br /><searchLink fieldCode="AR" term="%22Makara%2C+Michael+A%22">Makara, Michael A</searchLink><br /><searchLink fieldCode="AR" term="%22Brophy%2C+Peter+J%22">Brophy, Peter J</searchLink><br /><searchLink fieldCode="AR" term="%22Cooper%2C+Edward+C%22">Cooper, Edward C</searchLink><br /><searchLink fieldCode="AR" term="%22Bennett%2C+Vann%22">Bennett, Vann</searchLink><br /><searchLink fieldCode="AR" term="%22Mohler%2C+Peter+J%22">Mohler, Peter J</searchLink><br /><searchLink fieldCode="AR" term="%22Rasband%2C+Matthew+N%22">Rasband, Matthew N</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Dec2014, Vol. 17 Issue 12, p1673-1681. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ankyrins%22">Ankyrins</searchLink><br /><searchLink fieldCode="DE" term="%22Glial+fibrillary+acidic+protein%22">Glial fibrillary acidic protein</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system%22">Nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Neuron-glia interactions establish functional membrane domains along myelinated axons. These include nodes of Ranvier, paranodal axoglial junctions and juxtaparanodes. Paranodal junctions are the largest vertebrate junctional adhesion complex, and they are essential for rapid saltatory conduction and contribute to assembly and maintenance of nodes. However, the molecular mechanisms underlying paranodal junction assembly are poorly understood. Ankyrins are cytoskeletal scaffolds traditionally associated with Na+ channel clustering in neurons and are important for membrane domain establishment and maintenance in many cell types. Here we show that ankyrin-B, expressed by Schwann cells, and ankyrin-G, expressed by oligodendrocytes, are highly enriched at the glial side of paranodal junctions where they interact with the essential glial junctional component neurofascin 155. Conditional knockout of ankyrins in oligodendrocytes disrupts paranodal junction assembly and delays nerve conduction during early development in mice. Thus, glial ankyrins function as major scaffolds that facilitate early and efficient paranodal junction assembly in the developing CNS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nn.3858 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1673 Subjects: – SubjectFull: Ankyrins Type: general – SubjectFull: Glial fibrillary acidic protein Type: general – SubjectFull: Neurons Type: general – SubjectFull: Nervous system Type: general – SubjectFull: Neurosciences Type: general Titles: – TitleFull: Glial ankyrins facilitate paranodal axoglial junction assembly. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chang, Kae-Jiun – PersonEntity: Name: NameFull: Zollinger, Daniel R – PersonEntity: Name: NameFull: Susuki, Keiichiro – PersonEntity: Name: NameFull: Sherman, Diane L – PersonEntity: Name: NameFull: Makara, Michael A – PersonEntity: Name: NameFull: Brophy, Peter J – PersonEntity: Name: NameFull: Cooper, Edward C – PersonEntity: Name: NameFull: Bennett, Vann – PersonEntity: Name: NameFull: Mohler, Peter J – PersonEntity: Name: NameFull: Rasband, Matthew N IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 17 – Type: issue Value: 12 Titles: – TitleFull: Nature Neuroscience Type: main |
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