View in EDS PDF Full Text

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.

Saved in:
Bibliographic Details
Title: Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.
Authors: Brickman, Adam M, Khan, Usman A, Provenzano, Frank A, Yeung, Lok-Kin, Suzuki, Wendy, Schroeter, Hagen, Wall, Melanie, Sloan, Richard P, Small, Scott A
Source: Nature Neuroscience. Dec2014, Vol. 17 Issue 12, p1798-1803. 6p.
Subjects: Dentate gyrus, Hippocampus (Brain), Flavanols, Flavonoids, Neurosciences
Abstract: The dentate gyrus (DG) is a region in the hippocampal formation whose function declines in association with human aging and is therefore considered to be a possible source of age-related memory decline. Causal evidence is needed, however, to show that DG-associated memory decline in otherwise healthy elders can be improved by interventions that enhance DG function. We addressed this issue by first using a high-resolution variant of functional magnetic resonance imaging (fMRI) to map the precise site of age-related DG dysfunction and to develop a cognitive task whose function localized to this anatomical site. Then, in a controlled randomized trial, we applied these tools to study healthy 50-69-year-old subjects who consumed either a high or low cocoa flavanol-containing diet for 3 months. A high-flavanol intervention was found to enhance DG function, as measured by fMRI and by cognitive testing. Our findings establish that DG dysfunction is a driver of age-related cognitive decline and suggest non-pharmacological means for its amelioration. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 100160774
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Brickman%2C+Adam+M%22">Brickman, Adam M</searchLink><br /><searchLink fieldCode="AR" term="%22Khan%2C+Usman+A%22">Khan, Usman A</searchLink><br /><searchLink fieldCode="AR" term="%22Provenzano%2C+Frank+A%22">Provenzano, Frank A</searchLink><br /><searchLink fieldCode="AR" term="%22Yeung%2C+Lok-Kin%22">Yeung, Lok-Kin</searchLink><br /><searchLink fieldCode="AR" term="%22Suzuki%2C+Wendy%22">Suzuki, Wendy</searchLink><br /><searchLink fieldCode="AR" term="%22Schroeter%2C+Hagen%22">Schroeter, Hagen</searchLink><br /><searchLink fieldCode="AR" term="%22Wall%2C+Melanie%22">Wall, Melanie</searchLink><br /><searchLink fieldCode="AR" term="%22Sloan%2C+Richard+P%22">Sloan, Richard P</searchLink><br /><searchLink fieldCode="AR" term="%22Small%2C+Scott+A%22">Small, Scott A</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Dec2014, Vol. 17 Issue 12, p1798-1803. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Dentate+gyrus%22">Dentate gyrus</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Flavanols%22">Flavanols</searchLink><br /><searchLink fieldCode="DE" term="%22Flavonoids%22">Flavonoids</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The dentate gyrus (DG) is a region in the hippocampal formation whose function declines in association with human aging and is therefore considered to be a possible source of age-related memory decline. Causal evidence is needed, however, to show that DG-associated memory decline in otherwise healthy elders can be improved by interventions that enhance DG function. We addressed this issue by first using a high-resolution variant of functional magnetic resonance imaging (fMRI) to map the precise site of age-related DG dysfunction and to develop a cognitive task whose function localized to this anatomical site. Then, in a controlled randomized trial, we applied these tools to study healthy 50-69-year-old subjects who consumed either a high or low cocoa flavanol-containing diet for 3 months. A high-flavanol intervention was found to enhance DG function, as measured by fMRI and by cognitive testing. Our findings establish that DG dysfunction is a driver of age-related cognitive decline and suggest non-pharmacological means for its amelioration. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=100160774
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/nn.3850
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1798
    Subjects:
      – SubjectFull: Dentate gyrus
        Type: general
      – SubjectFull: Hippocampus (Brain)
        Type: general
      – SubjectFull: Flavanols
        Type: general
      – SubjectFull: Flavonoids
        Type: general
      – SubjectFull: Neurosciences
        Type: general
    Titles:
      – TitleFull: Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Brickman, Adam M
      – PersonEntity:
          Name:
            NameFull: Khan, Usman A
      – PersonEntity:
          Name:
            NameFull: Provenzano, Frank A
      – PersonEntity:
          Name:
            NameFull: Yeung, Lok-Kin
      – PersonEntity:
          Name:
            NameFull: Suzuki, Wendy
      – PersonEntity:
          Name:
            NameFull: Schroeter, Hagen
      – PersonEntity:
          Name:
            NameFull: Wall, Melanie
      – PersonEntity:
          Name:
            NameFull: Sloan, Richard P
      – PersonEntity:
          Name:
            NameFull: Small, Scott A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 10976256
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Nature Neuroscience
              Type: main
ResultId 1