View in EDS PDF Full Text

Smoking is associated with mosaic loss of chromosome Y.

Saved in:
Bibliographic Details
Title: Smoking is associated with mosaic loss of chromosome Y.
Authors: Dumanski, Jan P., Rasi, Chiara, Lönn, Mikael, Davies, Hanna, Ingelsson, Martin, Giedraitis, Vilmantas, Lannfelt, Lars, Magnusson, Patrik K. E., Lindgren, Cecilia M., Morris, Andrew P., Cesarini, David, Johannesson, Magnus, Tiensuu Janson, Eva, Lind, Lars, Pedersen, Nancy L., Ingelsson, Erik, Forsberg, Lars A.
Source: Science (pre-March 2025). 1/2/2015, Vol. 347 Issue 6217, p81-83. 3p.
Subjects: Smoking, Y chromosome, Blood cells, Mutagens, Single nucleotide polymorphisms, Tumor risk factors, Disease incidence, Cohort analysis
Abstract: Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non--sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 100211327
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Smoking is associated with mosaic loss of chromosome Y.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Dumanski%2C+Jan+P%2E%22">Dumanski, Jan P.</searchLink><br /><searchLink fieldCode="AR" term="%22Rasi%2C+Chiara%22">Rasi, Chiara</searchLink><br /><searchLink fieldCode="AR" term="%22Lönn%2C+Mikael%22">Lönn, Mikael</searchLink><br /><searchLink fieldCode="AR" term="%22Davies%2C+Hanna%22">Davies, Hanna</searchLink><br /><searchLink fieldCode="AR" term="%22Ingelsson%2C+Martin%22">Ingelsson, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Giedraitis%2C+Vilmantas%22">Giedraitis, Vilmantas</searchLink><br /><searchLink fieldCode="AR" term="%22Lannfelt%2C+Lars%22">Lannfelt, Lars</searchLink><br /><searchLink fieldCode="AR" term="%22Magnusson%2C+Patrik+K%2E+E%2E%22">Magnusson, Patrik K. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lindgren%2C+Cecilia+M%2E%22">Lindgren, Cecilia M.</searchLink><br /><searchLink fieldCode="AR" term="%22Morris%2C+Andrew+P%2E%22">Morris, Andrew P.</searchLink><br /><searchLink fieldCode="AR" term="%22Cesarini%2C+David%22">Cesarini, David</searchLink><br /><searchLink fieldCode="AR" term="%22Johannesson%2C+Magnus%22">Johannesson, Magnus</searchLink><br /><searchLink fieldCode="AR" term="%22Tiensuu+Janson%2C+Eva%22">Tiensuu Janson, Eva</searchLink><br /><searchLink fieldCode="AR" term="%22Lind%2C+Lars%22">Lind, Lars</searchLink><br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Nancy+L%2E%22">Pedersen, Nancy L.</searchLink><br /><searchLink fieldCode="AR" term="%22Ingelsson%2C+Erik%22">Ingelsson, Erik</searchLink><br /><searchLink fieldCode="AR" term="%22Forsberg%2C+Lars+A%2E%22">Forsberg, Lars A.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 1/2/2015, Vol. 347 Issue 6217, p81-83. 3p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br /><searchLink fieldCode="DE" term="%22Y+chromosome%22">Y chromosome</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+cells%22">Blood cells</searchLink><br /><searchLink fieldCode="DE" term="%22Mutagens%22">Mutagens</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+risk+factors%22">Tumor risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+incidence%22">Disease incidence</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non--sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=100211327
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.1262092
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 3
        StartPage: 81
    Subjects:
      – SubjectFull: Smoking
        Type: general
      – SubjectFull: Y chromosome
        Type: general
      – SubjectFull: Blood cells
        Type: general
      – SubjectFull: Mutagens
        Type: general
      – SubjectFull: Single nucleotide polymorphisms
        Type: general
      – SubjectFull: Tumor risk factors
        Type: general
      – SubjectFull: Disease incidence
        Type: general
      – SubjectFull: Cohort analysis
        Type: general
    Titles:
      – TitleFull: Smoking is associated with mosaic loss of chromosome Y.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Dumanski, Jan P.
      – PersonEntity:
          Name:
            NameFull: Rasi, Chiara
      – PersonEntity:
          Name:
            NameFull: Lönn, Mikael
      – PersonEntity:
          Name:
            NameFull: Davies, Hanna
      – PersonEntity:
          Name:
            NameFull: Ingelsson, Martin
      – PersonEntity:
          Name:
            NameFull: Giedraitis, Vilmantas
      – PersonEntity:
          Name:
            NameFull: Lannfelt, Lars
      – PersonEntity:
          Name:
            NameFull: Magnusson, Patrik K. E.
      – PersonEntity:
          Name:
            NameFull: Lindgren, Cecilia M.
      – PersonEntity:
          Name:
            NameFull: Morris, Andrew P.
      – PersonEntity:
          Name:
            NameFull: Cesarini, David
      – PersonEntity:
          Name:
            NameFull: Johannesson, Magnus
      – PersonEntity:
          Name:
            NameFull: Tiensuu Janson, Eva
      – PersonEntity:
          Name:
            NameFull: Lind, Lars
      – PersonEntity:
          Name:
            NameFull: Pedersen, Nancy L.
      – PersonEntity:
          Name:
            NameFull: Ingelsson, Erik
      – PersonEntity:
          Name:
            NameFull: Forsberg, Lars A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 01
              Text: 1/2/2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 347
            – Type: issue
              Value: 6217
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1