ADHD: Sibling Interaction or Dominance: An Evaluation of Statistical Power.
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| Title: | ADHD: Sibling Interaction or Dominance: An Evaluation of Statistical Power. |
|---|---|
| Authors: | Rietveld, M.J.H., Posthuma, D., Dolan, C.V., Boomsma, D.I. |
| Source: | Behavior Genetics. May2003, Vol. 33 Issue 3, p247-255. 9p. 6 Charts. |
| Subjects: | Siblings, Attention-deficit hyperactivity disorder, Behavior genetics |
| Abstract: | Sibling interaction effects are suggested by a difference in phenotypic variance between monozygotic (MZ) twins and dizygotic (DZ) twins, and a pattern of twin correlations that is inconsistent with additive genetic influences. Notably, negative sibling interaction will result in MZ correlations which are more than twice as high as DZ correlations, a pattern also seen in the presence of genetic dominance. Negative sibling interaction effects have been reported in most genetic studies on Attention Deficit Hyperactivity Disorder (ADHD) and related phenotypes, while the presence of genetic dominance is not always considered in these studies. In the present paper the statistical power to detect both negative sibling interaction effects and genetic dominance is explored. Power calculations are presented for univariate models including sources of variation due to additive genetic influences, unique environmental influences, dominant genetic influences and a negative sibling interaction (i.e., contrast effect) between phenotypes of twins. Parameter values for heritability and contrast effects are chosen in accordance with published behavior genetic studies on ADHD and associated phenotypes. Results show that when both genetic dominance and contrast effects are truly present and using a classical twin design, genetic dominance is more likely to go undetected than the contrast effect. Failure to detect the presence of genetic dominance consequently gives rise to slightly biased estimates of additive genetic effects, unique environmental effects, and the contrast effect. Contrast effects are more easily detected in the absence of genetic dominance. If the significance of the contrast effect is evaluated while also including genetic dominance, small contrast effects are likely to go undetected, resulting in a relatively large bias in estimates of the other parameters. Alternative genetic designs, such as adding pairs of unrelated siblings reared together to a classical... [ABSTRACT FROM AUTHOR] |
| Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 10036978 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ADHD: Sibling Interaction or Dominance: An Evaluation of Statistical Power. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rietveld%2C+M%2EJ%2EH%2E%22">Rietveld, M.J.H.</searchLink><br /><searchLink fieldCode="AR" term="%22Posthuma%2C+D%2E%22">Posthuma, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Dolan%2C+C%2EV%2E%22">Dolan, C.V.</searchLink><br /><searchLink fieldCode="AR" term="%22Boomsma%2C+D%2EI%2E%22">Boomsma, D.I.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Behavior+Genetics%22">Behavior Genetics</searchLink>. May2003, Vol. 33 Issue 3, p247-255. 9p. 6 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Siblings%22">Siblings</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+genetics%22">Behavior genetics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Sibling interaction effects are suggested by a difference in phenotypic variance between monozygotic (MZ) twins and dizygotic (DZ) twins, and a pattern of twin correlations that is inconsistent with additive genetic influences. Notably, negative sibling interaction will result in MZ correlations which are more than twice as high as DZ correlations, a pattern also seen in the presence of genetic dominance. Negative sibling interaction effects have been reported in most genetic studies on Attention Deficit Hyperactivity Disorder (ADHD) and related phenotypes, while the presence of genetic dominance is not always considered in these studies. In the present paper the statistical power to detect both negative sibling interaction effects and genetic dominance is explored. Power calculations are presented for univariate models including sources of variation due to additive genetic influences, unique environmental influences, dominant genetic influences and a negative sibling interaction (i.e., contrast effect) between phenotypes of twins. Parameter values for heritability and contrast effects are chosen in accordance with published behavior genetic studies on ADHD and associated phenotypes. Results show that when both genetic dominance and contrast effects are truly present and using a classical twin design, genetic dominance is more likely to go undetected than the contrast effect. Failure to detect the presence of genetic dominance consequently gives rise to slightly biased estimates of additive genetic effects, unique environmental effects, and the contrast effect. Contrast effects are more easily detected in the absence of genetic dominance. If the significance of the contrast effect is evaluated while also including genetic dominance, small contrast effects are likely to go undetected, resulting in a relatively large bias in estimates of the other parameters. Alternative genetic designs, such as adding pairs of unrelated siblings reared together to a classical... [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1023/A:1023490307170 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 247 Subjects: – SubjectFull: Siblings Type: general – SubjectFull: Attention-deficit hyperactivity disorder Type: general – SubjectFull: Behavior genetics Type: general Titles: – TitleFull: ADHD: Sibling Interaction or Dominance: An Evaluation of Statistical Power. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rietveld, M.J.H. – PersonEntity: Name: NameFull: Posthuma, D. – PersonEntity: Name: NameFull: Dolan, C.V. – PersonEntity: Name: NameFull: Boomsma, D.I. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00018244 Numbering: – Type: volume Value: 33 – Type: issue Value: 3 Titles: – TitleFull: Behavior Genetics Type: main |
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