Bibliographic Details
| Title: |
Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD. |
| Authors: |
Kadziela-Olech, Halina, Cichocki, Piotr, Chwiesko, Justyna, Konstantynowicz, Jerzy, Braszko, Jan |
| Source: |
European Child & Adolescent Psychiatry. Jan2015, Vol. 24 Issue 1, p55-63. 9p. 2 Charts, 2 Graphs. |
| Subjects: |
Academic medical centers, Attention-deficit hyperactivity disorder, Intelligence tests, Men's health, Nonparametric statistics, Scientific observation, Regression analysis, Research funding, Statistics, Wechsler Adult Intelligence Scale, Data analysis, Severity of illness index, Descriptive statistics, Matrix metalloproteinases, Mann Whitney U Test, Symptoms, Children |
| Geographic Terms: |
Poland |
| Abstract: |
The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD ( β = 0.33; p = 0.043) and HKD ( β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain ( β = 0.38; p = 0.019). [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
