Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD.
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| Title: | Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD. |
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| Authors: | Kadziela-Olech, Halina, Cichocki, Piotr, Chwiesko, Justyna, Konstantynowicz, Jerzy, Braszko, Jan |
| Source: | European Child & Adolescent Psychiatry. Jan2015, Vol. 24 Issue 1, p55-63. 9p. 2 Charts, 2 Graphs. |
| Subjects: | Academic medical centers, Attention-deficit hyperactivity disorder, Intelligence tests, Men's health, Nonparametric statistics, Scientific observation, Regression analysis, Research funding, Statistics, Wechsler Adult Intelligence Scale, Data analysis, Severity of illness index, Descriptive statistics, Matrix metalloproteinases, Mann Whitney U Test, Symptoms, Children |
| Geographic Terms: | Poland |
| Abstract: | The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD ( β = 0.33; p = 0.043) and HKD ( β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain ( β = 0.38; p = 0.019). [ABSTRACT FROM AUTHOR] |
| Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 100372251 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kadziela-Olech%2C+Halina%22">Kadziela-Olech, Halina</searchLink><br /><searchLink fieldCode="AR" term="%22Cichocki%2C+Piotr%22">Cichocki, Piotr</searchLink><br /><searchLink fieldCode="AR" term="%22Chwiesko%2C+Justyna%22">Chwiesko, Justyna</searchLink><br /><searchLink fieldCode="AR" term="%22Konstantynowicz%2C+Jerzy%22">Konstantynowicz, Jerzy</searchLink><br /><searchLink fieldCode="AR" term="%22Braszko%2C+Jan%22">Braszko, Jan</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Jan2015, Vol. 24 Issue 1, p55-63. 9p. 2 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence+tests%22">Intelligence tests</searchLink><br /><searchLink fieldCode="DE" term="%22Men's+health%22">Men's health</searchLink><br /><searchLink fieldCode="DE" term="%22Nonparametric+statistics%22">Nonparametric statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+observation%22">Scientific observation</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Wechsler+Adult+Intelligence+Scale%22">Wechsler Adult Intelligence Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Matrix+metalloproteinases%22">Matrix metalloproteinases</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Poland%22">Poland</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD ( β = 0.33; p = 0.043) and HKD ( β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain ( β = 0.38; p = 0.019). [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=100372251 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00787-014-0533-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 55 Subjects: – SubjectFull: Academic medical centers Type: general – SubjectFull: Attention-deficit hyperactivity disorder Type: general – SubjectFull: Intelligence tests Type: general – SubjectFull: Men's health Type: general – SubjectFull: Nonparametric statistics Type: general – SubjectFull: Scientific observation Type: general – SubjectFull: Regression analysis Type: general – SubjectFull: Research funding Type: general – SubjectFull: Statistics Type: general – SubjectFull: Wechsler Adult Intelligence Scale Type: general – SubjectFull: Data analysis Type: general – SubjectFull: Severity of illness index Type: general – SubjectFull: Descriptive statistics Type: general – SubjectFull: Matrix metalloproteinases Type: general – SubjectFull: Mann Whitney U Test Type: general – SubjectFull: Symptoms Type: general – SubjectFull: Children Type: general – SubjectFull: Poland Type: general Titles: – TitleFull: Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kadziela-Olech, Halina – PersonEntity: Name: NameFull: Cichocki, Piotr – PersonEntity: Name: NameFull: Chwiesko, Justyna – PersonEntity: Name: NameFull: Konstantynowicz, Jerzy – PersonEntity: Name: NameFull: Braszko, Jan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 10188827 Numbering: – Type: volume Value: 24 – Type: issue Value: 1 Titles: – TitleFull: European Child & Adolescent Psychiatry Type: main |
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