Cholinergic neurons of the basal forebrain mediate biochemical and electrophysiological mechanisms underlying sleep homeostasis.
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| Title: | Cholinergic neurons of the basal forebrain mediate biochemical and electrophysiological mechanisms underlying sleep homeostasis. |
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| Authors: | Kalinchuk, Anna V., Porkka-Heiskanen, Tarja, McCarley, Robert W., Basheer, Radhika |
| Source: | European Journal of Neuroscience. Jan2015, Vol. 41 Issue 2, p182-195. 14p. |
| Subjects: | Cholinergic mechanisms, Neurons, Prosencephalon, Biochemistry, Electrophysiology, Homeostasis, Nitric-oxide synthases |
| Abstract: | The tight coordination of biochemical and electrophysiological mechanisms underlies the homeostatic sleep pressure ( HSP) produced by sleep deprivation ( SD). We have reported that during SD the levels of inducible nitric oxide synthase (i NOS), extracellular nitric oxide ( NO), adenosine [ AD]ex, lactate [ Lac]ex and pyruvate [ Pyr]ex increase in the basal forebrain ( BF). However, it is not clear whether all of them contribute to HSP leading to increased electroencephalogram ( EEG) delta activity during non-rapid eye movement ( NREM) recovery sleep ( RS) following SD. Previously, we showed that NREM delta increase evident during RS depends on the presence of BF cholinergic ( Ch BF) neurons. Here, we investigated the role of Ch BF cells in coordination of biochemical and EEG changes seen during SD and RS in the rat. Increases in low-theta power (5-7 Hz), but not high-theta (7-9 Hz), during SD correlated with the increase in NREM delta power during RS, and with the changes in nitrate/nitrite [ NOx]ex and [ AD]ex. Lesions of Ch BF cells using Ig G 192-saporin prevented increases in [ NOx]ex, [ AD]ex and low-theta activity, during SD, but did not prevent increases in [ Lac]ex and [ Pyr]ex. Infusion of NO donor DETA NONOate into the saporin-treated BF failed to increase NREM RS and delta power, suggesting Ch BF cells are important for mediating NO homeostatic effects. Finally, SD-induced i NOS was mostly expressed in Ch BF cells, and the intensity of iNOS induction correlated with the increase in low-theta activity. Together, our data indicate ChBF cells are important in regulating the biochemical and EEG mechanisms that contribute to HSP. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 100488799 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cholinergic neurons of the basal forebrain mediate biochemical and electrophysiological mechanisms underlying sleep homeostasis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kalinchuk%2C+Anna+V%2E%22">Kalinchuk, Anna V.</searchLink><br /><searchLink fieldCode="AR" term="%22Porkka-Heiskanen%2C+Tarja%22">Porkka-Heiskanen, Tarja</searchLink><br /><searchLink fieldCode="AR" term="%22McCarley%2C+Robert+W%2E%22">McCarley, Robert W.</searchLink><br /><searchLink fieldCode="AR" term="%22Basheer%2C+Radhika%22">Basheer, Radhika</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jan2015, Vol. 41 Issue 2, p182-195. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cholinergic+mechanisms%22">Cholinergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Prosencephalon%22">Prosencephalon</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Electrophysiology%22">Electrophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink><br /><searchLink fieldCode="DE" term="%22Nitric-oxide+synthases%22">Nitric-oxide synthases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The tight coordination of biochemical and electrophysiological mechanisms underlies the homeostatic sleep pressure ( HSP) produced by sleep deprivation ( SD). We have reported that during SD the levels of inducible nitric oxide synthase (i NOS), extracellular nitric oxide ( NO), adenosine [ AD]ex, lactate [ Lac]ex and pyruvate [ Pyr]ex increase in the basal forebrain ( BF). However, it is not clear whether all of them contribute to HSP leading to increased electroencephalogram ( EEG) delta activity during non-rapid eye movement ( NREM) recovery sleep ( RS) following SD. Previously, we showed that NREM delta increase evident during RS depends on the presence of BF cholinergic ( Ch BF) neurons. Here, we investigated the role of Ch BF cells in coordination of biochemical and EEG changes seen during SD and RS in the rat. Increases in low-theta power (5-7 Hz), but not high-theta (7-9 Hz), during SD correlated with the increase in NREM delta power during RS, and with the changes in nitrate/nitrite [ NOx]ex and [ AD]ex. Lesions of Ch BF cells using Ig G 192-saporin prevented increases in [ NOx]ex, [ AD]ex and low-theta activity, during SD, but did not prevent increases in [ Lac]ex and [ Pyr]ex. Infusion of NO donor DETA NONOate into the saporin-treated BF failed to increase NREM RS and delta power, suggesting Ch BF cells are important for mediating NO homeostatic effects. Finally, SD-induced i NOS was mostly expressed in Ch BF cells, and the intensity of iNOS induction correlated with the increase in low-theta activity. Together, our data indicate ChBF cells are important in regulating the biochemical and EEG mechanisms that contribute to HSP. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.12766 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 182 Subjects: – SubjectFull: Cholinergic mechanisms Type: general – SubjectFull: Neurons Type: general – SubjectFull: Prosencephalon Type: general – SubjectFull: Biochemistry Type: general – SubjectFull: Electrophysiology Type: general – SubjectFull: Homeostasis Type: general – SubjectFull: Nitric-oxide synthases Type: general Titles: – TitleFull: Cholinergic neurons of the basal forebrain mediate biochemical and electrophysiological mechanisms underlying sleep homeostasis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kalinchuk, Anna V. – PersonEntity: Name: NameFull: Porkka-Heiskanen, Tarja – PersonEntity: Name: NameFull: McCarley, Robert W. – PersonEntity: Name: NameFull: Basheer, Radhika IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 01 Text: Jan2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 41 – Type: issue Value: 2 Titles: – TitleFull: European Journal of Neuroscience Type: main |
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