Neuropsychological functioning of children treated for acute lymphoblastic leukemia: impact of whole brain radiation therapy.
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| Title: | Neuropsychological functioning of children treated for acute lymphoblastic leukemia: impact of whole brain radiation therapy. |
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| Authors: | Annett, Robert D., Hile, Sarah, Bedrick, Edward, Kunin‐Batson, Alicia S., Krull, Kevin R., Embry, Leanne, MacLean, Willliam E., Noll, Robert B. |
| Source: | Psycho-Oncology. Feb2015, Vol. 24 Issue 2, p181-189. 9p. 3 Charts, 2 Graphs. |
| Subjects: | Neuropsychological tests for children, Lymphoblastic leukemia in children, Radiotherapy, Verbal ability in children, Child development testing, Leukemia treatment |
| Abstract: | Objectives To provide one of the first prospective reports examining neuropsychological outcomes for children treated with 1800 cGy whole brain radiotherapy (WBRT) and prophylactic chemotherapy versus prophylactic chemotherapy alone for acute lymphoblastic leukemia (ALL). Acute and long-term neuropsychological toxicities associated with WBRT are compared. Methods This multisite study included 188 children, ages 4-21 years at enrollment, who were assessed with standardized neuropsychological tests at 9, 21, and 48 months after diagnosis with intermediate risk ALL. All participating children were receiving treatment on a parent study CCG105. Results Verbal intelligence (VIQ) scores for children receiving WBRT was significantly lower than VIQ for prophylactic chemotherapy at the 48-month time point ( p < 0.05). A significant cross-level interaction between time since diagnosis and treatment condition was observed ( p < 0.05). WBRT did not result in differences in PIQ; both groups of children demonstrated comparable increases in PIQ. Neuropsychological findings at 48 months after diagnosis indicated diminished performance in neuromotor, visual-motor coordination, and executive functioning for children receiving WBRT. Academic achievement was unaffected by WBRT at 4 years after diagnosis. Conclusions The measurement of verbal and performance IQ as a primary endpoint in ALL clinical trials is critical to characterizing neuropsychological late effects. A trajectory of decline in neuropsychological functioning, specifically verbal IQ, was observed. Missing data within the trial occurred at random and did not impact results observed. The impact of WBRT becomes evident at 48 months after diagnosis, suggesting the need for long-term follow-up beyond the time frame typically used in Phase III trials. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 100524836 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neuropsychological functioning of children treated for acute lymphoblastic leukemia: impact of whole brain radiation therapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Annett%2C+Robert+D%2E%22">Annett, Robert D.</searchLink><br /><searchLink fieldCode="AR" term="%22Hile%2C+Sarah%22">Hile, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Bedrick%2C+Edward%22">Bedrick, Edward</searchLink><br /><searchLink fieldCode="AR" term="%22Kunin‐Batson%2C+Alicia+S%2E%22">Kunin‐Batson, Alicia S.</searchLink><br /><searchLink fieldCode="AR" term="%22Krull%2C+Kevin+R%2E%22">Krull, Kevin R.</searchLink><br /><searchLink fieldCode="AR" term="%22Embry%2C+Leanne%22">Embry, Leanne</searchLink><br /><searchLink fieldCode="AR" term="%22MacLean%2C+Willliam+E%2E%22">MacLean, Willliam E.</searchLink><br /><searchLink fieldCode="AR" term="%22Noll%2C+Robert+B%2E%22">Noll, Robert B.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psycho-Oncology%22">Psycho-Oncology</searchLink>. Feb2015, Vol. 24 Issue 2, p181-189. 9p. 3 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neuropsychological+tests+for+children%22">Neuropsychological tests for children</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphoblastic+leukemia+in+children%22">Lymphoblastic leukemia in children</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Verbal+ability+in+children%22">Verbal ability in children</searchLink><br /><searchLink fieldCode="DE" term="%22Child+development+testing%22">Child development testing</searchLink><br /><searchLink fieldCode="DE" term="%22Leukemia+treatment%22">Leukemia treatment</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives To provide one of the first prospective reports examining neuropsychological outcomes for children treated with 1800 cGy whole brain radiotherapy (WBRT) and prophylactic chemotherapy versus prophylactic chemotherapy alone for acute lymphoblastic leukemia (ALL). Acute and long-term neuropsychological toxicities associated with WBRT are compared. Methods This multisite study included 188 children, ages 4-21 years at enrollment, who were assessed with standardized neuropsychological tests at 9, 21, and 48 months after diagnosis with intermediate risk ALL. All participating children were receiving treatment on a parent study CCG105. Results Verbal intelligence (VIQ) scores for children receiving WBRT was significantly lower than VIQ for prophylactic chemotherapy at the 48-month time point ( p < 0.05). A significant cross-level interaction between time since diagnosis and treatment condition was observed ( p < 0.05). WBRT did not result in differences in PIQ; both groups of children demonstrated comparable increases in PIQ. Neuropsychological findings at 48 months after diagnosis indicated diminished performance in neuromotor, visual-motor coordination, and executive functioning for children receiving WBRT. Academic achievement was unaffected by WBRT at 4 years after diagnosis. Conclusions The measurement of verbal and performance IQ as a primary endpoint in ALL clinical trials is critical to characterizing neuropsychological late effects. A trajectory of decline in neuropsychological functioning, specifically verbal IQ, was observed. Missing data within the trial occurred at random and did not impact results observed. The impact of WBRT becomes evident at 48 months after diagnosis, suggesting the need for long-term follow-up beyond the time frame typically used in Phase III trials. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/pon.3586 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 181 Subjects: – SubjectFull: Neuropsychological tests for children Type: general – SubjectFull: Lymphoblastic leukemia in children Type: general – SubjectFull: Radiotherapy Type: general – SubjectFull: Verbal ability in children Type: general – SubjectFull: Child development testing Type: general – SubjectFull: Leukemia treatment Type: general Titles: – TitleFull: Neuropsychological functioning of children treated for acute lymphoblastic leukemia: impact of whole brain radiation therapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Annett, Robert D. – PersonEntity: Name: NameFull: Hile, Sarah – PersonEntity: Name: NameFull: Bedrick, Edward – PersonEntity: Name: NameFull: Kunin‐Batson, Alicia S. – PersonEntity: Name: NameFull: Krull, Kevin R. – PersonEntity: Name: NameFull: Embry, Leanne – PersonEntity: Name: NameFull: MacLean, Willliam E. – PersonEntity: Name: NameFull: Noll, Robert B. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 10579249 Numbering: – Type: volume Value: 24 – Type: issue Value: 2 Titles: – TitleFull: Psycho-Oncology Type: main |
| ResultId | 1 |
