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Ten-year prognosis in multiple sclerosis: a better outcome in relapsing−remitting patients but not in primary progressive patients.

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Title: Ten-year prognosis in multiple sclerosis: a better outcome in relapsing−remitting patients but not in primary progressive patients.
Authors: Kerbrat, A., Hamonic, S., Leray, E., Tron, I., Edan, G., Yaouanq, J.
Source: European Journal of Neurology. Mar2015, Vol. 22 Issue 3, p507-507. 8p.
Subjects: Multiple sclerosis, Disease relapse, Disease progression, Medical practice, Physicians, Prognosis
Abstract: Background and purpose Multiple sclerosis ( MS) prognosis remains a challenge for both patients and physicians. Complementary to natural history studies, updated population-based data from the first event suggestive of MS, at the time of the first approved disease modifying drug ( DMD), are needed. Our objective was to provide a 10-year history of MS from clinical onset at time of first approved DMDs in a population-based cohort. Methods A population-based cohort of patients whose first clinical event suggestive of MS had occurred in Brittany between 2000 and 2001 was prospectively selected. History of relapses, treatments and disability up to 10 years after onset were collected. Results In all, 278 patients with either attack-onset ( n = 244) or progressive-onset ( n = 34) were recruited. Amongst attack-onset patients, 30% remained as clinically isolated syndrome and 70% had a second relapse after a median time of 1.7 years (95% confidence interval 1.2-2.4). 80% of relapsing−remitting MS patients received DMDs for at least 6 months. 29% reached disability status scale ( DSS) 3 and 8% DSS 6. Amongst progressive-onset patients, 100% reached DSS 3 and 59% DSS 6. Conclusion(s) Our population-based study reports a lower risk of disability progression at 10-year follow-up in the relapsing−remitting MS group than previously reported. This better prognosis was not observed in the progressive-onset MS group. This finding impacts the prognosis given to patients in clinical practice. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Ten-year prognosis in multiple sclerosis: a better outcome in relapsing−remitting patients but not in primary progressive patients.
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  Data: <searchLink fieldCode="AR" term="%22Kerbrat%2C+A%2E%22">Kerbrat, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Hamonic%2C+S%2E%22">Hamonic, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Leray%2C+E%2E%22">Leray, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Tron%2C+I%2E%22">Tron, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Edan%2C+G%2E%22">Edan, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Yaouanq%2C+J%2E%22">Yaouanq, J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Mar2015, Vol. 22 Issue 3, p507-507. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse%22">Disease relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+practice%22">Medical practice</searchLink><br /><searchLink fieldCode="DE" term="%22Physicians%22">Physicians</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose Multiple sclerosis ( MS) prognosis remains a challenge for both patients and physicians. Complementary to natural history studies, updated population-based data from the first event suggestive of MS, at the time of the first approved disease modifying drug ( DMD), are needed. Our objective was to provide a 10-year history of MS from clinical onset at time of first approved DMDs in a population-based cohort. Methods A population-based cohort of patients whose first clinical event suggestive of MS had occurred in Brittany between 2000 and 2001 was prospectively selected. History of relapses, treatments and disability up to 10 years after onset were collected. Results In all, 278 patients with either attack-onset ( n = 244) or progressive-onset ( n = 34) were recruited. Amongst attack-onset patients, 30% remained as clinically isolated syndrome and 70% had a second relapse after a median time of 1.7 years (95% confidence interval 1.2-2.4). 80% of relapsing−remitting MS patients received DMDs for at least 6 months. 29% reached disability status scale ( DSS) 3 and 8% DSS 6. Amongst progressive-onset patients, 100% reached DSS 3 and 59% DSS 6. Conclusion(s) Our population-based study reports a lower risk of disability progression at 10-year follow-up in the relapsing−remitting MS group than previously reported. This better prognosis was not observed in the progressive-onset MS group. This finding impacts the prognosis given to patients in clinical practice. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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