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Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa.

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Title: Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa.
Authors: Dossat, Amanda M., Bodell, Lindsay P., Williams, Diana L., Eckel, Lisa A., Keel, Pamela K.
Source: International Journal of Eating Disorders. Mar2015, Vol. 48 Issue 2, p199-205. 7p. 2 Graphs.
Subjects: Analysis of variance, Bulimia, Comparative studies, Enzyme-linked immunosorbent assay, Interviewing, Research methodology, Research funding, Statistics, Glucagon-like peptide 1, Data analysis, Body mass index, Visual analog scale, Repeated measures design
Abstract: ABSTRACT Objective This study examined pre- and postprandial glucagon-like peptide 1 (GLP-1) levels in women with bulimia nervosa (BN), purging disorder (PD), and non-eating disorder control women to better understand whether alterations in satiation-related hormones in BN may be linked to binge-eating episodes or other altered ingestive behaviors. Method Participants included women with BN ( n = 19), PD ( n = 14), or controls ( n = 14). Participants provided subjective ratings for hunger and fullness and plasma samples before and after consumption of a standardized test meal. Results As expected, GLP-1 levels increased significantly following test meal consumption; however, participants with BN displayed significantly lower GLP-1 levels compared to PD and control participants both before and after consumption of the test meal. There were no significant differences between PD and control participants in GLP-1 levels, but individuals with PD displayed significantly higher levels of fullness throughout the test meal as compared to both control and BN participants. Discussion Our findings provide preliminary evidence that reduced GLP-1 levels in individuals with BN may be associated with binge-eating episodes. Additionally, increased fullness in individuals with PD does not appear to be accounted for by exaggerated postprandial GLP-1 release. © 2014 Wiley Periodicals, Inc. Int J Eat Disord 2015; 48:199-205 [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa.
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Eating+Disorders%22">International Journal of Eating Disorders</searchLink>. Mar2015, Vol. 48 Issue 2, p199-205. 7p. 2 Graphs.
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  Data: ABSTRACT Objective This study examined pre- and postprandial glucagon-like peptide 1 (GLP-1) levels in women with bulimia nervosa (BN), purging disorder (PD), and non-eating disorder control women to better understand whether alterations in satiation-related hormones in BN may be linked to binge-eating episodes or other altered ingestive behaviors. Method Participants included women with BN ( n = 19), PD ( n = 14), or controls ( n = 14). Participants provided subjective ratings for hunger and fullness and plasma samples before and after consumption of a standardized test meal. Results As expected, GLP-1 levels increased significantly following test meal consumption; however, participants with BN displayed significantly lower GLP-1 levels compared to PD and control participants both before and after consumption of the test meal. There were no significant differences between PD and control participants in GLP-1 levels, but individuals with PD displayed significantly higher levels of fullness throughout the test meal as compared to both control and BN participants. Discussion Our findings provide preliminary evidence that reduced GLP-1 levels in individuals with BN may be associated with binge-eating episodes. Additionally, increased fullness in individuals with PD does not appear to be accounted for by exaggerated postprandial GLP-1 release. © 2014 Wiley Periodicals, Inc. Int J Eat Disord 2015; 48:199-205 [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=100952770
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        Value: 10.1002/eat.22264
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        StartPage: 199
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      – SubjectFull: Analysis of variance
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      – SubjectFull: Bulimia
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      – SubjectFull: Comparative studies
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      – SubjectFull: Research funding
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      – SubjectFull: Statistics
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      – SubjectFull: Glucagon-like peptide 1
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      – SubjectFull: Body mass index
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      – SubjectFull: Visual analog scale
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      – SubjectFull: Repeated measures design
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              Text: Mar2015
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