Beyond the usual suspects: histamine and ADHD.
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| Title: | Beyond the usual suspects: histamine and ADHD. |
|---|---|
| Authors: | Turic, D. (AUTHOR), Cornforth, C. M. (AUTHOR), Thompson, M. (AUTHOR), Sonuga-Barke, E. J. (AUTHOR) |
| Source: | European Child & Adolescent Psychiatry. Jun2010, Vol. 19, pS30-S31. 2p. |
| Abstract: | Introduction and aim: Histamine, despite being the neurotransmitter with versatile roles and having influence on numerous brain functions, has been rarely examined in the ADHD field. The aim of this research is to explore whether genes controlling brain histamine are implicated in ADHD. Methods: Licensed drugs target the catecholamine system—especially the dopamine system. While effective in the short term at reducing symptoms their long-term benefits appear limited. It is important to develop novel drugs that target alternative brain systems. Results: Stevenson et al. (2010) have recently produced the first line of evidence of a link between histamine genes and ADHD. Functional polymorphisms of HNMT involved in the degradation of histamine moderated the effects of exposure to artificial food additives in a large double blind trial in children. Discussion: Histamine is involved in a wide range of physiological functions including learning and memory, and locomotion. The evidence suggests a potential role of histamine in the pathophysiology of ADHD. Conclusion: Recently published molecular genetic data combined with animal studies showing the role of histamine in ADHD-related cognitive processes, suggest that the histamine system as an interesting target in ADHD. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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