Bibliographic Details
| Title: |
Insulin secretory granules control autophagy in pancreatic β cells. |
| Authors: |
Goginashvili, Alexander, Zhirong Zhang, Erbs, Eric, Spiegelhalter, Coralie, Kessler, Pascal, Mihlan, Michael, Pasquier, Adrien, Krupina, Ksenia, Schieber, Nicole, Cinque, Laura, Morvan, Joëlle, Sumara, Izabela, Schwab, Yannick, Settembre, Carmine, Ricci, Romeo |
| Source: |
Science (pre-March 2025). 2/20/2015, Vol. 347 Issue 6224, p878-882. 5p. |
| Subjects: |
Pancreatic beta cells, Autophagy, Cytoplasmic granules, Insulin, Starvation, Lysosomes, Protein kinases |
| Abstract: |
The article focuses on the role of insulin secretory granules in controlling macroautophagy in pancreatic beta cells. It states that starvation resulted in the suppression of macroautophagy in pancreatic beta cells and instead induced lysosomal degradation of protein kinase D-controlled nascent secretory insulin granules. It commented on the role of insulin granule degradation in keeping secretion of insulin low during fasting. |
| Database: |
Psychology and Behavioral Sciences Collection |
