Insulin secretory granules control autophagy in pancreatic β cells.
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| Title: | Insulin secretory granules control autophagy in pancreatic β cells. |
|---|---|
| Authors: | Goginashvili, Alexander, Zhirong Zhang, Erbs, Eric, Spiegelhalter, Coralie, Kessler, Pascal, Mihlan, Michael, Pasquier, Adrien, Krupina, Ksenia, Schieber, Nicole, Cinque, Laura, Morvan, Joëlle, Sumara, Izabela, Schwab, Yannick, Settembre, Carmine, Ricci, Romeo |
| Source: | Science (pre-March 2025). 2/20/2015, Vol. 347 Issue 6224, p878-882. 5p. |
| Subjects: | Pancreatic beta cells, Autophagy, Cytoplasmic granules, Insulin, Starvation, Lysosomes, Protein kinases |
| Abstract: | The article focuses on the role of insulin secretory granules in controlling macroautophagy in pancreatic beta cells. It states that starvation resulted in the suppression of macroautophagy in pancreatic beta cells and instead induced lysosomal degradation of protein kinase D-controlled nascent secretory insulin granules. It commented on the role of insulin granule degradation in keeping secretion of insulin low during fasting. |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 101076937 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Insulin secretory granules control autophagy in pancreatic β cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Goginashvili%2C+Alexander%22">Goginashvili, Alexander</searchLink><br /><searchLink fieldCode="AR" term="%22Zhirong+Zhang%22">Zhirong Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Erbs%2C+Eric%22">Erbs, Eric</searchLink><br /><searchLink fieldCode="AR" term="%22Spiegelhalter%2C+Coralie%22">Spiegelhalter, Coralie</searchLink><br /><searchLink fieldCode="AR" term="%22Kessler%2C+Pascal%22">Kessler, Pascal</searchLink><br /><searchLink fieldCode="AR" term="%22Mihlan%2C+Michael%22">Mihlan, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Pasquier%2C+Adrien%22">Pasquier, Adrien</searchLink><br /><searchLink fieldCode="AR" term="%22Krupina%2C+Ksenia%22">Krupina, Ksenia</searchLink><br /><searchLink fieldCode="AR" term="%22Schieber%2C+Nicole%22">Schieber, Nicole</searchLink><br /><searchLink fieldCode="AR" term="%22Cinque%2C+Laura%22">Cinque, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Morvan%2C+Joëlle%22">Morvan, Joëlle</searchLink><br /><searchLink fieldCode="AR" term="%22Sumara%2C+Izabela%22">Sumara, Izabela</searchLink><br /><searchLink fieldCode="AR" term="%22Schwab%2C+Yannick%22">Schwab, Yannick</searchLink><br /><searchLink fieldCode="AR" term="%22Settembre%2C+Carmine%22">Settembre, Carmine</searchLink><br /><searchLink fieldCode="AR" term="%22Ricci%2C+Romeo%22">Ricci, Romeo</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 2/20/2015, Vol. 347 Issue 6224, p878-882. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Pancreatic+beta+cells%22">Pancreatic beta cells</searchLink><br /><searchLink fieldCode="DE" term="%22Autophagy%22">Autophagy</searchLink><br /><searchLink fieldCode="DE" term="%22Cytoplasmic+granules%22">Cytoplasmic granules</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin%22">Insulin</searchLink><br /><searchLink fieldCode="DE" term="%22Starvation%22">Starvation</searchLink><br /><searchLink fieldCode="DE" term="%22Lysosomes%22">Lysosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article focuses on the role of insulin secretory granules in controlling macroautophagy in pancreatic beta cells. It states that starvation resulted in the suppression of macroautophagy in pancreatic beta cells and instead induced lysosomal degradation of protein kinase D-controlled nascent secretory insulin granules. It commented on the role of insulin granule degradation in keeping secretion of insulin low during fasting. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=101076937 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.aaa2628 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 878 Subjects: – SubjectFull: Pancreatic beta cells Type: general – SubjectFull: Autophagy Type: general – SubjectFull: Cytoplasmic granules Type: general – SubjectFull: Insulin Type: general – SubjectFull: Starvation Type: general – SubjectFull: Lysosomes Type: general – SubjectFull: Protein kinases Type: general Titles: – TitleFull: Insulin secretory granules control autophagy in pancreatic β cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Goginashvili, Alexander – PersonEntity: Name: NameFull: Zhirong Zhang – PersonEntity: Name: NameFull: Erbs, Eric – PersonEntity: Name: NameFull: Spiegelhalter, Coralie – PersonEntity: Name: NameFull: Kessler, Pascal – PersonEntity: Name: NameFull: Mihlan, Michael – PersonEntity: Name: NameFull: Pasquier, Adrien – PersonEntity: Name: NameFull: Krupina, Ksenia – PersonEntity: Name: NameFull: Schieber, Nicole – PersonEntity: Name: NameFull: Cinque, Laura – PersonEntity: Name: NameFull: Morvan, Joëlle – PersonEntity: Name: NameFull: Sumara, Izabela – PersonEntity: Name: NameFull: Schwab, Yannick – PersonEntity: Name: NameFull: Settembre, Carmine – PersonEntity: Name: NameFull: Ricci, Romeo IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 02 Text: 2/20/2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 347 – Type: issue Value: 6224 Titles: – TitleFull: Science (pre-March 2025) Type: main |
| ResultId | 1 |
