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Sensorimotor neural dynamics during isochronous tapping in the medial premotor cortex of the macaque.

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Title: Sensorimotor neural dynamics during isochronous tapping in the medial premotor cortex of the macaque.
Authors: Merchant, Hugo, Pérez, Oswaldo, Bartolo, Ramón, Méndez, Juan Carlos, Mendoza, Germán, Gámez, Jorge, Yc, Karyna, Prado, Luis
Source: European Journal of Neuroscience. Mar2015, Vol. 41 Issue 5, p586-602. 17p. 1 Diagram, 3 Charts, 10 Graphs.
Subjects: Sensorimotor cortex, Isochronous cyclotrons, Premotor cortex, Macaques, Stimulus & response (Biology)
Abstract: We determined the response properties of neurons in the primate medial premotor cortex that were classified as sensory or motor during isochronous tapping to a visual or auditory metronome, using different target intervals and three sequential elements in the task. The cell classification was based on a warping transformation, which determined whether the cell activity was statistically aligned to sensory or motor events, finding a large proportion of cells classified as sensory or motor. Two distinctive clusters of sensory cells were observed, i.e. one cell population with short response-onset latencies to the previous stimulus, and another that was probably predicting the occurrence of the next stimuli. These cells were called sensory-driven and stimulus-predicting neurons, respectively. Sensory-driven neurons showed a clear bias towards the visual modality and were more responsive to the first stimulus, with a decrease in activity for the following sequential elements of the metronome. In contrast, stimulus-predicting neurons were bimodal and showed similar response profiles across serial-order elements. Motor cells showed a consecutive activity onset across discrete neural ensembles, generating a rapid succession of activation patterns between the two taps defining a produced interval. The cyclical configuration in activation profiles engaged more motor cells as the serial-order elements progressed across the task, and the rate of cell recruitment over time decreased as a function of the target interval. Our findings support the idea that motor cells were responsible for the rhythmic progression of taps in the task, gaining more importance as the trial advanced, while, simultaneously, the sensory-driven cells lost their functional impact. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Sensorimotor neural dynamics during isochronous tapping in the medial premotor cortex of the macaque.
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  Data: <searchLink fieldCode="AR" term="%22Merchant%2C+Hugo%22">Merchant, Hugo</searchLink><br /><searchLink fieldCode="AR" term="%22Pérez%2C+Oswaldo%22">Pérez, Oswaldo</searchLink><br /><searchLink fieldCode="AR" term="%22Bartolo%2C+Ramón%22">Bartolo, Ramón</searchLink><br /><searchLink fieldCode="AR" term="%22Méndez%2C+Juan+Carlos%22">Méndez, Juan Carlos</searchLink><br /><searchLink fieldCode="AR" term="%22Mendoza%2C+Germán%22">Mendoza, Germán</searchLink><br /><searchLink fieldCode="AR" term="%22Gámez%2C+Jorge%22">Gámez, Jorge</searchLink><br /><searchLink fieldCode="AR" term="%22Yc%2C+Karyna%22">Yc, Karyna</searchLink><br /><searchLink fieldCode="AR" term="%22Prado%2C+Luis%22">Prado, Luis</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2015, Vol. 41 Issue 5, p586-602. 17p. 1 Diagram, 3 Charts, 10 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Sensorimotor+cortex%22">Sensorimotor cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Isochronous+cyclotrons%22">Isochronous cyclotrons</searchLink><br /><searchLink fieldCode="DE" term="%22Premotor+cortex%22">Premotor cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Macaques%22">Macaques</searchLink><br /><searchLink fieldCode="DE" term="%22Stimulus+%26+response+%28Biology%29%22">Stimulus & response (Biology)</searchLink>
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  Label: Abstract
  Group: Ab
  Data: We determined the response properties of neurons in the primate medial premotor cortex that were classified as sensory or motor during isochronous tapping to a visual or auditory metronome, using different target intervals and three sequential elements in the task. The cell classification was based on a warping transformation, which determined whether the cell activity was statistically aligned to sensory or motor events, finding a large proportion of cells classified as sensory or motor. Two distinctive clusters of sensory cells were observed, i.e. one cell population with short response-onset latencies to the previous stimulus, and another that was probably predicting the occurrence of the next stimuli. These cells were called sensory-driven and stimulus-predicting neurons, respectively. Sensory-driven neurons showed a clear bias towards the visual modality and were more responsive to the first stimulus, with a decrease in activity for the following sequential elements of the metronome. In contrast, stimulus-predicting neurons were bimodal and showed similar response profiles across serial-order elements. Motor cells showed a consecutive activity onset across discrete neural ensembles, generating a rapid succession of activation patterns between the two taps defining a produced interval. The cyclical configuration in activation profiles engaged more motor cells as the serial-order elements progressed across the task, and the rate of cell recruitment over time decreased as a function of the target interval. Our findings support the idea that motor cells were responsible for the rhythmic progression of taps in the task, gaining more importance as the trial advanced, while, simultaneously, the sensory-driven cells lost their functional impact. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.12811
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        Text: English
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      – SubjectFull: Premotor cortex
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      – SubjectFull: Macaques
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      – SubjectFull: Stimulus & response (Biology)
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              Text: Mar2015
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