Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey.
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| Title: | Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey. |
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| Authors: | Needham, B L, Mezuk, B, Bareis, N, Lin, J, Blackburn, E H, Epel, E S |
| Source: | Molecular Psychiatry. Apr2015, Vol. 20 Issue 4, p520-528. 9p. |
| Subjects: | Mental depression, Telomeres, Psychological stress, Anxiety disorders, Panic disorders, Antidepressants |
| Abstract: | Telomere length has been hypothesized to be a marker of cumulative exposure to stress, and stress is an established cause of depression and anxiety disorders. The aim of this study was to examine the relationship between depression, anxiety and telomere length, and to assess whether this relationship is moderated by race/ethnicity, gender and/or antidepressant use. Data were from the 1999-2002 National Health and Nutrition Examination Survey. Telomere length was assessed using the quantitative PCR method of telomere length relative to standard reference DNA. Past-year major depression (MD), generalized anxiety disorder (GAD) and panic disorder (PD), as well as depressed affect and anxious affect, were assessed using the Composite International Diagnostic Inventory (N=1290). Multiple linear regression was used to assess the relationship between depression and anxiety disorders and telomere length. Among women, those with GAD or PD had shorter telomeres than those with no anxious affect (β: −0.07, P<0.01), but there was no relationship among men (β: 0.08, P>0.05). Among respondents currently taking an antidepressant, those with MD had shorter telomeres than those without (β: −0.26, P<0.05), but there was no association between MD and telomere length among those not using antidepressants (β: −0.00, P>0.05). Neither depressive nor anxiety disorders were directly associated with telomere length in young adults. There was suggestive evidence that pharmacologically treated MD is associated with shorter telomere length, likely reflecting the more severe nature of MD that has come to clinical attention. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 101683945 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Needham%2C+B+L%22">Needham, B L</searchLink><br /><searchLink fieldCode="AR" term="%22Mezuk%2C+B%22">Mezuk, B</searchLink><br /><searchLink fieldCode="AR" term="%22Bareis%2C+N%22">Bareis, N</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+J%22">Lin, J</searchLink><br /><searchLink fieldCode="AR" term="%22Blackburn%2C+E+H%22">Blackburn, E H</searchLink><br /><searchLink fieldCode="AR" term="%22Epel%2C+E+S%22">Epel, E S</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Apr2015, Vol. 20 Issue 4, p520-528. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Telomeres%22">Telomeres</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Panic+disorders%22">Panic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Telomere length has been hypothesized to be a marker of cumulative exposure to stress, and stress is an established cause of depression and anxiety disorders. The aim of this study was to examine the relationship between depression, anxiety and telomere length, and to assess whether this relationship is moderated by race/ethnicity, gender and/or antidepressant use. Data were from the 1999-2002 National Health and Nutrition Examination Survey. Telomere length was assessed using the quantitative PCR method of telomere length relative to standard reference DNA. Past-year major depression (MD), generalized anxiety disorder (GAD) and panic disorder (PD), as well as depressed affect and anxious affect, were assessed using the Composite International Diagnostic Inventory (N=1290). Multiple linear regression was used to assess the relationship between depression and anxiety disorders and telomere length. Among women, those with GAD or PD had shorter telomeres than those with no anxious affect (β: −0.07, P<0.01), but there was no relationship among men (β: 0.08, P>0.05). Among respondents currently taking an antidepressant, those with MD had shorter telomeres than those without (β: −0.26, P<0.05), but there was no association between MD and telomere length among those not using antidepressants (β: −0.00, P>0.05). Neither depressive nor anxiety disorders were directly associated with telomere length in young adults. There was suggestive evidence that pharmacologically treated MD is associated with shorter telomere length, likely reflecting the more severe nature of MD that has come to clinical attention. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2014.89 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 520 Subjects: – SubjectFull: Mental depression Type: general – SubjectFull: Telomeres Type: general – SubjectFull: Psychological stress Type: general – SubjectFull: Anxiety disorders Type: general – SubjectFull: Panic disorders Type: general – SubjectFull: Antidepressants Type: general Titles: – TitleFull: Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Needham, B L – PersonEntity: Name: NameFull: Mezuk, B – PersonEntity: Name: NameFull: Bareis, N – PersonEntity: Name: NameFull: Lin, J – PersonEntity: Name: NameFull: Blackburn, E H – PersonEntity: Name: NameFull: Epel, E S IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 20 – Type: issue Value: 4 Titles: – TitleFull: Molecular Psychiatry Type: main |
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