Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter.
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| Title: | Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. |
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| Authors: | Puterman, E, Lin, J, Krauss, J, Blackburn, E H, Epel, E S |
| Source: | Molecular Psychiatry. Apr2015, Vol. 20 Issue 4, p529-535. 7p. |
| Subjects: | Telomeres, Psychological stress, Women's health, Postmenopause, Health behavior, Chronic diseases |
| Abstract: | Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress and health behaviors. Cross-sectionally, highly stressed postmenopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere length change over a short period, and if rate of attrition is affected by naturalistic factors such as stress and engagement in healthy behaviors, including diet, exercise, and sleep. Here we followed healthy women over 1 year to test if major stressors that occurred over the year predicted telomere shortening, and whether engaging in healthy behaviors during this period mitigates this effect. In 239 postmenopausal, non-smoking, disease-free women, accumulation of major life stressors across a 1-year period predicted telomere attrition over the same period-for every major life stressor that occurred during the year, there was a significantly greater decline in telomere length over the year of 35 bp (P<0.05). Yet, these effects were moderated by health behaviors (interaction B=0.19, P=0.04). Women who maintained relatively higher levels of health behaviors (1 s.d. above the mean) appeared to be protected when exposed to stress. This finding has implications for understanding malleability of telomere length, as well as expectations for possible intervention effects. This is the first study to identify predictors of telomere length change over the short period of a year. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 101683959 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Puterman%2C+E%22">Puterman, E</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+J%22">Lin, J</searchLink><br /><searchLink fieldCode="AR" term="%22Krauss%2C+J%22">Krauss, J</searchLink><br /><searchLink fieldCode="AR" term="%22Blackburn%2C+E+H%22">Blackburn, E H</searchLink><br /><searchLink fieldCode="AR" term="%22Epel%2C+E+S%22">Epel, E S</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Apr2015, Vol. 20 Issue 4, p529-535. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Telomeres%22">Telomeres</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Women's+health%22">Women's health</searchLink><br /><searchLink fieldCode="DE" term="%22Postmenopause%22">Postmenopause</searchLink><br /><searchLink fieldCode="DE" term="%22Health+behavior%22">Health behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress and health behaviors. Cross-sectionally, highly stressed postmenopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere length change over a short period, and if rate of attrition is affected by naturalistic factors such as stress and engagement in healthy behaviors, including diet, exercise, and sleep. Here we followed healthy women over 1 year to test if major stressors that occurred over the year predicted telomere shortening, and whether engaging in healthy behaviors during this period mitigates this effect. In 239 postmenopausal, non-smoking, disease-free women, accumulation of major life stressors across a 1-year period predicted telomere attrition over the same period-for every major life stressor that occurred during the year, there was a significantly greater decline in telomere length over the year of 35 bp (P<0.05). Yet, these effects were moderated by health behaviors (interaction B=0.19, P=0.04). Women who maintained relatively higher levels of health behaviors (1 s.d. above the mean) appeared to be protected when exposed to stress. This finding has implications for understanding malleability of telomere length, as well as expectations for possible intervention effects. This is the first study to identify predictors of telomere length change over the short period of a year. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2014.70 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 529 Subjects: – SubjectFull: Telomeres Type: general – SubjectFull: Psychological stress Type: general – SubjectFull: Women's health Type: general – SubjectFull: Postmenopause Type: general – SubjectFull: Health behavior Type: general – SubjectFull: Chronic diseases Type: general Titles: – TitleFull: Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Puterman, E – PersonEntity: Name: NameFull: Lin, J – PersonEntity: Name: NameFull: Krauss, J – PersonEntity: Name: NameFull: Blackburn, E H – PersonEntity: Name: NameFull: Epel, E S IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 20 – Type: issue Value: 4 Titles: – TitleFull: Molecular Psychiatry Type: main |
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