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Increased bilirubin levels in de novo Parkinson's disease.

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Title: Increased bilirubin levels in de novo Parkinson's disease.
Authors: Moccia, M., Picillo, M., Erro, R., Longo, K., Amboni, M., Santangelo, G., Palladino, R., Allocca, R., Caporale, O., Triassi, M., Pellecchia, M. T., Barone, P., Vitale, C.
Source: European Journal of Neurology. Jun2015, Vol. 22 Issue 6, p954-959. 6p. 1 Chart, 3 Graphs.
Subjects: Bilirubin, Parkinson's disease, Bile pigments, Extrapyramidal disorders, Oxidative stress
Abstract: Background and purpose Oxidative stress is a central pathogenic mechanism of Parkinson's disease ( PD), and the heme oxygenase ( HO) bilirubin pathway is one of the main mammalian antioxidative defences. Indeed, there is growing evidence of HO−bilirubin upregulation from early phases of PD. Our aim was to investigate bilirubin as a possible biomarker of PD diagnosis and progression. Methods A cross-sectional case−control study was performed to evaluate differences in bilirubin levels between newly diagnosed, drug-naïve PD subjects and controls. Afterwards, PD subjects were included in a 2-year longitudinal study to evaluate disease progression in relation to baseline bilirubin levels. Results Seventy-five de novo PD subjects were selected and matched with 75 controls by propensity score. Analysis of variance showed higher bilirubin levels in PD patients compared with controls ( P < 0.001). Linear regression analysis failed to show a relationship between bilirubin and Unified Parkinson's Disease Rating Scale ( UPDRS) part III ( P = 0.283) at baseline evaluation. At 2-year follow-up, indirect relationships between bilirubin levels and UPDRS part III ( P = 0.028) and between bilirubin levels and levodopa-equivalent daily dosage ( P = 0.012) were found. Conclusions Parkinson's disease subjects showed higher levels of bilirubin compared with controls. Bilirubin increase might be due to HO overexpression as a compensatory response to oxidative stress occurring from early stages of PD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Increased bilirubin levels in de novo Parkinson&#39;s disease.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Moccia%2C+M%2E%22&quot;&gt;Moccia, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Picillo%2C+M%2E%22&quot;&gt;Picillo, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Erro%2C+R%2E%22&quot;&gt;Erro, R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Longo%2C+K%2E%22&quot;&gt;Longo, K.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Amboni%2C+M%2E%22&quot;&gt;Amboni, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Santangelo%2C+G%2E%22&quot;&gt;Santangelo, G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Palladino%2C+R%2E%22&quot;&gt;Palladino, R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Allocca%2C+R%2E%22&quot;&gt;Allocca, R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Caporale%2C+O%2E%22&quot;&gt;Caporale, O.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Triassi%2C+M%2E%22&quot;&gt;Triassi, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pellecchia%2C+M%2E+T%2E%22&quot;&gt;Pellecchia, M. T.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Barone%2C+P%2E%22&quot;&gt;Barone, P.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vitale%2C+C%2E%22&quot;&gt;Vitale, C.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Jun2015, Vol. 22 Issue 6, p954-959. 6p. 1 Chart, 3 Graphs.
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  Data: Background and purpose Oxidative stress is a central pathogenic mechanism of Parkinson&#39;s disease ( PD), and the heme oxygenase ( HO) bilirubin pathway is one of the main mammalian antioxidative defences. Indeed, there is growing evidence of HO−bilirubin upregulation from early phases of PD. Our aim was to investigate bilirubin as a possible biomarker of PD diagnosis and progression. Methods A cross-sectional case−control study was performed to evaluate differences in bilirubin levels between newly diagnosed, drug-na&#239;ve PD subjects and controls. Afterwards, PD subjects were included in a 2-year longitudinal study to evaluate disease progression in relation to baseline bilirubin levels. Results Seventy-five de novo PD subjects were selected and matched with 75 controls by propensity score. Analysis of variance showed higher bilirubin levels in PD patients compared with controls ( P &lt; 0.001). Linear regression analysis failed to show a relationship between bilirubin and Unified Parkinson&#39;s Disease Rating Scale ( UPDRS) part III ( P = 0.283) at baseline evaluation. At 2-year follow-up, indirect relationships between bilirubin levels and UPDRS part III ( P = 0.028) and between bilirubin levels and levodopa-equivalent daily dosage ( P = 0.012) were found. Conclusions Parkinson&#39;s disease subjects showed higher levels of bilirubin compared with controls. Bilirubin increase might be due to HO overexpression as a compensatory response to oxidative stress occurring from early stages of PD. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=102271819
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        Value: 10.1111/ene.12688
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