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Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.

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Title: Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.
Authors: Tsuboi, Daisuke, Kuroda, Keisuke, Tanaka, Motoki, Namba, Takashi, Iizuka, Yukihiko, Taya, Shinichiro, Shinoda, Tomoyasu, Hikita, Takao, Muraoka, Shinsuke, Iizuka, Michiro, Nimura, Ai, Mizoguchi, Akira, Shiina, Nobuyuki, Sokabe, Masahiro, Okano, Hideyuki, Mikoshiba, Katsuhiko, Kaibuchi, Kozo
Source: Nature Neuroscience. May2015, Vol. 18 Issue 5, p698-707. 10p. 2 Diagrams, 5 Graphs.
Subjects: Schizophrenia, Pathological psychology, Laboratory mice, Messenger RNA, Carrier proteins
Abstract: Disrupted-in-schizophrenia 1 (DISC1) is a susceptibility gene for major psychiatric disorders, including schizophrenia. DISC1 has been implicated in neurodevelopment in relation to scaffolding signal complexes. Here we used proteomic analysis to screen for DISC1 interactors and identified several RNA-binding proteins, such as hematopoietic zinc finger (HZF), that act as components of RNA-transporting granules. HZF participates in the mRNA localization of inositol-1,4,5-trisphosphate receptor type 1 (ITPR1), which plays a key role in synaptic plasticity. DISC1 colocalizes with HZF and ITPR1 mRNA in hippocampal dendrites and directly associates with neuronal mRNAs, including ITPR1 mRNA. The binding potential of DISC1 for ITPR1 mRNA is facilitated by HZF. Studies of Disc1-knockout mice have revealed that DISC1 regulates the dendritic transport of Itpr1 mRNA by directly interacting with its mRNA. The DISC1-mediated mRNA regulation is involved in synaptic plasticity. We show that DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.
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  Data: <searchLink fieldCode="AR" term="%22Tsuboi%2C+Daisuke%22">Tsuboi, Daisuke</searchLink><br /><searchLink fieldCode="AR" term="%22Kuroda%2C+Keisuke%22">Kuroda, Keisuke</searchLink><br /><searchLink fieldCode="AR" term="%22Tanaka%2C+Motoki%22">Tanaka, Motoki</searchLink><br /><searchLink fieldCode="AR" term="%22Namba%2C+Takashi%22">Namba, Takashi</searchLink><br /><searchLink fieldCode="AR" term="%22Iizuka%2C+Yukihiko%22">Iizuka, Yukihiko</searchLink><br /><searchLink fieldCode="AR" term="%22Taya%2C+Shinichiro%22">Taya, Shinichiro</searchLink><br /><searchLink fieldCode="AR" term="%22Shinoda%2C+Tomoyasu%22">Shinoda, Tomoyasu</searchLink><br /><searchLink fieldCode="AR" term="%22Hikita%2C+Takao%22">Hikita, Takao</searchLink><br /><searchLink fieldCode="AR" term="%22Muraoka%2C+Shinsuke%22">Muraoka, Shinsuke</searchLink><br /><searchLink fieldCode="AR" term="%22Iizuka%2C+Michiro%22">Iizuka, Michiro</searchLink><br /><searchLink fieldCode="AR" term="%22Nimura%2C+Ai%22">Nimura, Ai</searchLink><br /><searchLink fieldCode="AR" term="%22Mizoguchi%2C+Akira%22">Mizoguchi, Akira</searchLink><br /><searchLink fieldCode="AR" term="%22Shiina%2C+Nobuyuki%22">Shiina, Nobuyuki</searchLink><br /><searchLink fieldCode="AR" term="%22Sokabe%2C+Masahiro%22">Sokabe, Masahiro</searchLink><br /><searchLink fieldCode="AR" term="%22Okano%2C+Hideyuki%22">Okano, Hideyuki</searchLink><br /><searchLink fieldCode="AR" term="%22Mikoshiba%2C+Katsuhiko%22">Mikoshiba, Katsuhiko</searchLink><br /><searchLink fieldCode="AR" term="%22Kaibuchi%2C+Kozo%22">Kaibuchi, Kozo</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. May2015, Vol. 18 Issue 5, p698-707. 10p. 2 Diagrams, 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Carrier+proteins%22">Carrier proteins</searchLink>
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  Data: Disrupted-in-schizophrenia 1 (DISC1) is a susceptibility gene for major psychiatric disorders, including schizophrenia. DISC1 has been implicated in neurodevelopment in relation to scaffolding signal complexes. Here we used proteomic analysis to screen for DISC1 interactors and identified several RNA-binding proteins, such as hematopoietic zinc finger (HZF), that act as components of RNA-transporting granules. HZF participates in the mRNA localization of inositol-1,4,5-trisphosphate receptor type 1 (ITPR1), which plays a key role in synaptic plasticity. DISC1 colocalizes with HZF and ITPR1 mRNA in hippocampal dendrites and directly associates with neuronal mRNAs, including ITPR1 mRNA. The binding potential of DISC1 for ITPR1 mRNA is facilitated by HZF. Studies of Disc1-knockout mice have revealed that DISC1 regulates the dendritic transport of Itpr1 mRNA by directly interacting with its mRNA. The DISC1-mediated mRNA regulation is involved in synaptic plasticity. We show that DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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