Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor ( VIPR2) agonist.
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| Title: | Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor ( VIPR2) agonist. |
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| Authors: | Ago, Yukio, Condro, Michael, Tan, Yossan-Var, Ghiani, Cristina, Colwell, Christopher, Cushman, Jesse, Fanselow, Michael, Hashimoto, Hitoshi, Waschek, James |
| Source: | Psychopharmacology. Jun2015, Vol. 232 Issue 12, p2181-2189. 9p. |
| Subjects: | Neuroplasticity, Postnatal care, Vasoactive intestinal peptide, Laboratory mice, Synaptophysin, Social interaction |
| Abstract: | Rationale: An abundance of genetic and epidemiologic evidence as well as longitudinal neuroimaging data point to developmental origins for schizophrenia and other mental health disorders. Recent clinical studies indicate that microduplications of VIPR2, encoding the vasoactive intestinal peptide (VIP) receptor VPAC2, confer significant risk for schizophrenia and autism spectrum disorder. Lymphocytes from patients with these mutations exhibited higher VIPR2 gene expression and VIP responsiveness (cAMP induction), but mechanisms by which overactive VPAC2 signaling may lead to these psychiatric disorders are unknown. Objectives: We subcutaneously administered the highly selective VPAC2 receptor agonist Ro 25-1553 to C57BL/6 mice from postnatal day 1 (P1) to P14 to determine if overactivation of VPAC2 receptor signaling during postnatal brain maturation affects synaptogenesis and selected behaviors. Results: Western blot analyses on P21 revealed significant reductions of synaptophysin and postsynaptic density protein 95 (PSD-95) in the prefrontal cortex, but not in the hippocampus in Ro 25-1553-treated mice. The same postnatally restricted treatment resulted in a disruption in prepulse inhibition of the acoustic startle measured in adult mice. No effects were observed in open-field locomotor activity, sociability in the three-chamber social interaction test, or fear conditioning or extinction. Conclusion: Overactivation of the VPAC2 receptor in the postnatal mouse results in a reduction in synaptic proteins in the prefrontal cortex and selective alterations in prepulse inhibition. These findings suggest that the VIPR2-linkage to mental health disorders may be due in part to overactive VPAC2 receptor signaling during a critical time of synaptic maturation. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 102664948 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor ( VIPR2) agonist. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ago%2C+Yukio%22">Ago, Yukio</searchLink><br /><searchLink fieldCode="AR" term="%22Condro%2C+Michael%22">Condro, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Tan%2C+Yossan-Var%22">Tan, Yossan-Var</searchLink><br /><searchLink fieldCode="AR" term="%22Ghiani%2C+Cristina%22">Ghiani, Cristina</searchLink><br /><searchLink fieldCode="AR" term="%22Colwell%2C+Christopher%22">Colwell, Christopher</searchLink><br /><searchLink fieldCode="AR" term="%22Cushman%2C+Jesse%22">Cushman, Jesse</searchLink><br /><searchLink fieldCode="AR" term="%22Fanselow%2C+Michael%22">Fanselow, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Hashimoto%2C+Hitoshi%22">Hashimoto, Hitoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Waschek%2C+James%22">Waschek, James</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jun2015, Vol. 232 Issue 12, p2181-2189. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Postnatal+care%22">Postnatal care</searchLink><br /><searchLink fieldCode="DE" term="%22Vasoactive+intestinal+peptide%22">Vasoactive intestinal peptide</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Synaptophysin%22">Synaptophysin</searchLink><br /><searchLink fieldCode="DE" term="%22Social+interaction%22">Social interaction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: An abundance of genetic and epidemiologic evidence as well as longitudinal neuroimaging data point to developmental origins for schizophrenia and other mental health disorders. Recent clinical studies indicate that microduplications of VIPR2, encoding the vasoactive intestinal peptide (VIP) receptor VPAC2, confer significant risk for schizophrenia and autism spectrum disorder. Lymphocytes from patients with these mutations exhibited higher VIPR2 gene expression and VIP responsiveness (cAMP induction), but mechanisms by which overactive VPAC2 signaling may lead to these psychiatric disorders are unknown. Objectives: We subcutaneously administered the highly selective VPAC2 receptor agonist Ro 25-1553 to C57BL/6 mice from postnatal day 1 (P1) to P14 to determine if overactivation of VPAC2 receptor signaling during postnatal brain maturation affects synaptogenesis and selected behaviors. Results: Western blot analyses on P21 revealed significant reductions of synaptophysin and postsynaptic density protein 95 (PSD-95) in the prefrontal cortex, but not in the hippocampus in Ro 25-1553-treated mice. The same postnatally restricted treatment resulted in a disruption in prepulse inhibition of the acoustic startle measured in adult mice. No effects were observed in open-field locomotor activity, sociability in the three-chamber social interaction test, or fear conditioning or extinction. Conclusion: Overactivation of the VPAC2 receptor in the postnatal mouse results in a reduction in synaptic proteins in the prefrontal cortex and selective alterations in prepulse inhibition. These findings suggest that the VIPR2-linkage to mental health disorders may be due in part to overactive VPAC2 receptor signaling during a critical time of synaptic maturation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-014-3848-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 2181 Subjects: – SubjectFull: Neuroplasticity Type: general – SubjectFull: Postnatal care Type: general – SubjectFull: Vasoactive intestinal peptide Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Synaptophysin Type: general – SubjectFull: Social interaction Type: general Titles: – TitleFull: Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor ( VIPR2) agonist. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ago, Yukio – PersonEntity: Name: NameFull: Condro, Michael – PersonEntity: Name: NameFull: Tan, Yossan-Var – PersonEntity: Name: NameFull: Ghiani, Cristina – PersonEntity: Name: NameFull: Colwell, Christopher – PersonEntity: Name: NameFull: Cushman, Jesse – PersonEntity: Name: NameFull: Fanselow, Michael – PersonEntity: Name: NameFull: Hashimoto, Hitoshi – PersonEntity: Name: NameFull: Waschek, James IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: Jun2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 232 – Type: issue Value: 12 Titles: – TitleFull: Psychopharmacology Type: main |
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