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A cysteine-clamp gene drives embryo polarity in the midge Chironomus.

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Title: A cysteine-clamp gene drives embryo polarity in the midge Chironomus.
Authors: Klomp, Jeff, Athy, Derek, Chun Wai Kwan, Bloch, Natasha I., Sandmann, Thomas, Lemke, Steffen, Schmidt-Ott, Urs
Source: Science (pre-March 2025). 5/29/2015, Vol. 348 Issue 6238, p1040-1042. 3p.
Subjects: Cysteine, Chironomus riparius, Genes, Insect embryos, DNA-binding proteins, Gene regulatory networks
Abstract: In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A cysteine-clamp gene drives embryo polarity in the midge Chironomus.
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  Data: <searchLink fieldCode="AR" term="%22Klomp%2C+Jeff%22">Klomp, Jeff</searchLink><br /><searchLink fieldCode="AR" term="%22Athy%2C+Derek%22">Athy, Derek</searchLink><br /><searchLink fieldCode="AR" term="%22Chun+Wai+Kwan%22">Chun Wai Kwan</searchLink><br /><searchLink fieldCode="AR" term="%22Bloch%2C+Natasha+I%2E%22">Bloch, Natasha I.</searchLink><br /><searchLink fieldCode="AR" term="%22Sandmann%2C+Thomas%22">Sandmann, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Lemke%2C+Steffen%22">Lemke, Steffen</searchLink><br /><searchLink fieldCode="AR" term="%22Schmidt-Ott%2C+Urs%22">Schmidt-Ott, Urs</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 5/29/2015, Vol. 348 Issue 6238, p1040-1042. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Cysteine%22">Cysteine</searchLink><br /><searchLink fieldCode="DE" term="%22Chironomus+riparius%22">Chironomus riparius</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Insect+embryos%22">Insect embryos</searchLink><br /><searchLink fieldCode="DE" term="%22DNA-binding+proteins%22">DNA-binding proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+regulatory+networks%22">Gene regulatory networks</searchLink>
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  Data: In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=102930986
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        Value: 10.1126/science.aaa7105
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        Text: English
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        Type: general
      – SubjectFull: Chironomus riparius
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              Text: 5/29/2015
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