Association between TNF-α promoter −308 A/G polymorphism and Alzheimer's disease: a meta-analysis.
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| Title: | Association between TNF-α promoter −308 A/G polymorphism and Alzheimer's disease: a meta-analysis. |
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| Authors: | Lee, Young, Choi, Sung, Ji, Jong, Song, Gwan |
| Source: | Neurological Sciences. Jun2015, Vol. 36 Issue 6, p825-832. 8p. 5 Charts, 2 Graphs. |
| Subjects: | Tumor necrosis factors, Promoters (Genetics), Genetic polymorphisms, Alzheimer's disease, Meta-analysis, Disease susceptibility |
| Abstract: | The aim of this study was to determine whether the tumor necrosis factor-α (TNF-α) promoter −308 A/G polymorphism is associated with susceptibility to Alzheimer's disease (AD) in multi-ethnic populations. MEDLINE and EMBASE databases and manual literature search were used to identify published articles in which TNF-α polymorphism was determined in AD patients and control subjects. Meta-analysis was conducted on the association between the TNF-α −308 A/G polymorphism and AD using allele contrast and the recessive, dominant, and additive models. A total of 16 studies involving 3,826 AD patients and 4,327 control subjects were examined. The meta-analysis showed no association between the TNF-α −308 A allele and AD when all the subjects were considered [odds ratio (OR) = 1.275, 95 % CI 0.966-1.685, p = 0.087]. After stratification by ethnicity, the meta-analysis indicated that the A allele is significantly associated with AD in East Asian (OR = 1.743, 95 % CI 1.256-2.418, p = 0.001), but not in the European (OR = 0.963, 95 % CI 0.822-1.128, p = 0.637) or Middle Eastern populations (OR = 3.921, 95 % CI 0.411-37.42, p = 0.235). Meta-analysis under dominant, recessive, and additive models also showed a similar pattern of results as with the A allele. This meta-analysis shows that the TNF-α −308 A/G polymorphism may represent a significant risk factor for AD in East Asians but not in the European or Middle Eastern populations. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 103032719 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Association between TNF-α promoter −308 A/G polymorphism and Alzheimer's disease: a meta-analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lee%2C+Young%22">Lee, Young</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+Sung%22">Choi, Sung</searchLink><br /><searchLink fieldCode="AR" term="%22Ji%2C+Jong%22">Ji, Jong</searchLink><br /><searchLink fieldCode="AR" term="%22Song%2C+Gwan%22">Song, Gwan</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jun2015, Vol. 36 Issue 6, p825-832. 8p. 5 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tumor+necrosis+factors%22">Tumor necrosis factors</searchLink><br /><searchLink fieldCode="DE" term="%22Promoters+%28Genetics%29%22">Promoters (Genetics)</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+susceptibility%22">Disease susceptibility</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The aim of this study was to determine whether the tumor necrosis factor-α (TNF-α) promoter −308 A/G polymorphism is associated with susceptibility to Alzheimer's disease (AD) in multi-ethnic populations. MEDLINE and EMBASE databases and manual literature search were used to identify published articles in which TNF-α polymorphism was determined in AD patients and control subjects. Meta-analysis was conducted on the association between the TNF-α −308 A/G polymorphism and AD using allele contrast and the recessive, dominant, and additive models. A total of 16 studies involving 3,826 AD patients and 4,327 control subjects were examined. The meta-analysis showed no association between the TNF-α −308 A allele and AD when all the subjects were considered [odds ratio (OR) = 1.275, 95 % CI 0.966-1.685, p = 0.087]. After stratification by ethnicity, the meta-analysis indicated that the A allele is significantly associated with AD in East Asian (OR = 1.743, 95 % CI 1.256-2.418, p = 0.001), but not in the European (OR = 0.963, 95 % CI 0.822-1.128, p = 0.637) or Middle Eastern populations (OR = 3.921, 95 % CI 0.411-37.42, p = 0.235). Meta-analysis under dominant, recessive, and additive models also showed a similar pattern of results as with the A allele. This meta-analysis shows that the TNF-α −308 A/G polymorphism may represent a significant risk factor for AD in East Asians but not in the European or Middle Eastern populations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-015-2102-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 825 Subjects: – SubjectFull: Tumor necrosis factors Type: general – SubjectFull: Promoters (Genetics) Type: general – SubjectFull: Genetic polymorphisms Type: general – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Meta-analysis Type: general – SubjectFull: Disease susceptibility Type: general Titles: – TitleFull: Association between TNF-α promoter −308 A/G polymorphism and Alzheimer's disease: a meta-analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lee, Young – PersonEntity: Name: NameFull: Choi, Sung – PersonEntity: Name: NameFull: Ji, Jong – PersonEntity: Name: NameFull: Song, Gwan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 36 – Type: issue Value: 6 Titles: – TitleFull: Neurological Sciences Type: main |
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