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Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

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Title: Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.
Authors: Power, Robert A, Steinberg, Stacy, Bjornsdottir, Gyda, Rietveld, Cornelius A, Abdellaoui, Abdel, Nivard, Michel M, Johannesson, Magnus, Galesloot, Tessel E, Hottenga, Jouke J, Willemsen, Gonneke, Cesarini, David, Benjamin, Daniel J, Magnusson, Patrik K E, Ullén, Fredrik, Tiemeier, Henning, Hofman, Albert, van Rooij, Frank J A, Walters, G Bragi, Sigurdsson, Engilbert, Thorgeirsson, Thorgeir E
Source: Nature Neuroscience. Jul2015, Vol. 18 Issue 7, p953-955. 3p.
Subjects: Schizophrenia, Bipolar disorder, Mental illness, Affective disorders, Brain research
Abstract: We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10−6 and 3.8 × 10−6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Power%2C+Robert+A%22">Power, Robert A</searchLink><br /><searchLink fieldCode="AR" term="%22Steinberg%2C+Stacy%22">Steinberg, Stacy</searchLink><br /><searchLink fieldCode="AR" term="%22Bjornsdottir%2C+Gyda%22">Bjornsdottir, Gyda</searchLink><br /><searchLink fieldCode="AR" term="%22Rietveld%2C+Cornelius+A%22">Rietveld, Cornelius A</searchLink><br /><searchLink fieldCode="AR" term="%22Abdellaoui%2C+Abdel%22">Abdellaoui, Abdel</searchLink><br /><searchLink fieldCode="AR" term="%22Nivard%2C+Michel+M%22">Nivard, Michel M</searchLink><br /><searchLink fieldCode="AR" term="%22Johannesson%2C+Magnus%22">Johannesson, Magnus</searchLink><br /><searchLink fieldCode="AR" term="%22Galesloot%2C+Tessel+E%22">Galesloot, Tessel E</searchLink><br /><searchLink fieldCode="AR" term="%22Hottenga%2C+Jouke+J%22">Hottenga, Jouke J</searchLink><br /><searchLink fieldCode="AR" term="%22Willemsen%2C+Gonneke%22">Willemsen, Gonneke</searchLink><br /><searchLink fieldCode="AR" term="%22Cesarini%2C+David%22">Cesarini, David</searchLink><br /><searchLink fieldCode="AR" term="%22Benjamin%2C+Daniel+J%22">Benjamin, Daniel J</searchLink><br /><searchLink fieldCode="AR" term="%22Magnusson%2C+Patrik+K+E%22">Magnusson, Patrik K E</searchLink><br /><searchLink fieldCode="AR" term="%22Ullén%2C+Fredrik%22">Ullén, Fredrik</searchLink><br /><searchLink fieldCode="AR" term="%22Tiemeier%2C+Henning%22">Tiemeier, Henning</searchLink><br /><searchLink fieldCode="AR" term="%22Hofman%2C+Albert%22">Hofman, Albert</searchLink><br /><searchLink fieldCode="AR" term="%22van+Rooij%2C+Frank+J+A%22">van Rooij, Frank J A</searchLink><br /><searchLink fieldCode="AR" term="%22Walters%2C+G+Bragi%22">Walters, G Bragi</searchLink><br /><searchLink fieldCode="AR" term="%22Sigurdsson%2C+Engilbert%22">Sigurdsson, Engilbert</searchLink><br /><searchLink fieldCode="AR" term="%22Thorgeirsson%2C+Thorgeir+E%22">Thorgeirsson, Thorgeir E</searchLink>
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  Data: We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10−6 and 3.8 × 10−6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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