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The expanding field of IgG4-mediated neurological autoimmune disorders.

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Title: The expanding field of IgG4-mediated neurological autoimmune disorders.
Authors: Huijbers, M. G., Querol, L. A., Niks, E. H., Plomp, J. J., Maarel, S. M., Graus, F., Dalmau, J., Illa, I., Verschuuren, J. J.
Source: European Journal of Neurology. Aug2015, Vol. 22 Issue 8, p1151-1161. 11p. 1 Diagram, 1 Chart.
Subjects: Autoimmune disease diagnosis, Autoimmune diseases, Immunoglobulin G, Immunoglobulins, Immunology, Patients
Abstract: At least 13 different disease entities affecting the central nervous system, peripheral nervous system and connective tissue of the skin or kidneys are associated with immunoglobulin G4 (IgG4) immune reactivity. IgG4 has always been considered a benign, non-inflammatory subclass of IgG, in contrast to the well-known complement-activating pro-inflammatory IgG1 subclass. A comprehensive review of these IgG4 autoimmune disorders reveals striking similarities in epitope binding and human leukocyte antigen ( HLA) associations. Mechanical interference of extracellular ligand−receptor interactions by the associated IgG4 antibodies seems to be the common/converging disease mechanism in these disorders. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The expanding field of IgG4-mediated neurological autoimmune disorders.
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  Data: <searchLink fieldCode="AR" term="%22Huijbers%2C+M%2E+G%2E%22">Huijbers, M. G.</searchLink><br /><searchLink fieldCode="AR" term="%22Querol%2C+L%2E+A%2E%22">Querol, L. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Niks%2C+E%2E+H%2E%22">Niks, E. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Plomp%2C+J%2E+J%2E%22">Plomp, J. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Maarel%2C+S%2E+M%2E%22">Maarel, S. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Graus%2C+F%2E%22">Graus, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Dalmau%2C+J%2E%22">Dalmau, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Illa%2C+I%2E%22">Illa, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Verschuuren%2C+J%2E+J%2E%22">Verschuuren, J. J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Aug2015, Vol. 22 Issue 8, p1151-1161. 11p. 1 Diagram, 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Autoimmune+disease+diagnosis%22">Autoimmune disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Autoimmune+diseases%22">Autoimmune diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulin+G%22">Immunoglobulin G</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulins%22">Immunoglobulins</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Label: Abstract
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  Data: At least 13 different disease entities affecting the central nervous system, peripheral nervous system and connective tissue of the skin or kidneys are associated with immunoglobulin G4 (IgG4) immune reactivity. IgG4 has always been considered a benign, non-inflammatory subclass of IgG, in contrast to the well-known complement-activating pro-inflammatory IgG1 subclass. A comprehensive review of these IgG4 autoimmune disorders reveals striking similarities in epitope binding and human leukocyte antigen ( HLA) associations. Mechanical interference of extracellular ligand−receptor interactions by the associated IgG4 antibodies seems to be the common/converging disease mechanism in these disorders. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=103668434
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