p-ANCA pachymeningitis presenting with isolated "optic neuropathy".
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| Title: | p-ANCA pachymeningitis presenting with isolated "optic neuropathy". |
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| Authors: | Salvi F (AUTHOR), Mascalchi M (AUTHOR), Pasini E (AUTHOR), Bartolomei I (AUTHOR), Fini N (AUTHOR), Marliani F (AUTHOR), Malatesta R (AUTHOR), Michelucci R (AUTHOR), Salvi, Fabrizio (AUTHOR), Mascalchi, Mario (AUTHOR), Pasini, Elena (AUTHOR), Bartolomei, Ilaria (AUTHOR), Fini, Nicola (AUTHOR), Marliani, Federica (AUTHOR), Malatesta, Renato (AUTHOR), Michelucci, Roberto (AUTHOR) |
| Source: | Neurological Sciences. Oct2010, Vol. 31 Issue 5, p639-641. 3p. |
| Abstract: | Isolated bilateral optic neuropathy is an exceedingly rare presentation of perinuclear-antineutrophil cytoplasmic autoantibody (p-ANCA) vasculitis. We report one such case with MRI documentation of a compressive mechanism mediated by pachymeningitis. A 69-year-old woman had a 6-month history of progressive visual failure caused by bilateral optic neuropathy. Cranial MRI showed diffuse contrast enhancement of the dura mater extending to the perioptic sheaths bilaterally with encasement of the optic nerves. Extensive laboratory study showed increased levels of p-ANCA titres and autoimmune markers. Corticosteroid treatment improved both visual acuity and the neuroradiological signs of active pachymeningitis. In conclusion, our case demonstrates that bilateral optic neuropathy may be the presenting symptom of p-ANCA-associated pachymeningitis, whose causative role may be demonstrated by MRI. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 104924744 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: p-ANCA pachymeningitis presenting with isolated "optic neuropathy". – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Salvi+F%22">Salvi F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mascalchi+M%22">Mascalchi M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pasini+E%22">Pasini E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bartolomei+I%22">Bartolomei I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fini+N%22">Fini N</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marliani+F%22">Marliani F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Malatesta+R%22">Malatesta R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michelucci+R%22">Michelucci R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salvi%2C+Fabrizio%22">Salvi, Fabrizio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mascalchi%2C+Mario%22">Mascalchi, Mario</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pasini%2C+Elena%22">Pasini, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bartolomei%2C+Ilaria%22">Bartolomei, Ilaria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fini%2C+Nicola%22">Fini, Nicola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marliani%2C+Federica%22">Marliani, Federica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Malatesta%2C+Renato%22">Malatesta, Renato</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michelucci%2C+Roberto%22">Michelucci, Roberto</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Oct2010, Vol. 31 Issue 5, p639-641. 3p. – Name: Abstract Label: Abstract Group: Ab Data: Isolated bilateral optic neuropathy is an exceedingly rare presentation of perinuclear-antineutrophil cytoplasmic autoantibody (p-ANCA) vasculitis. We report one such case with MRI documentation of a compressive mechanism mediated by pachymeningitis. A 69-year-old woman had a 6-month history of progressive visual failure caused by bilateral optic neuropathy. Cranial MRI showed diffuse contrast enhancement of the dura mater extending to the perioptic sheaths bilaterally with encasement of the optic nerves. Extensive laboratory study showed increased levels of p-ANCA titres and autoimmune markers. Corticosteroid treatment improved both visual acuity and the neuroradiological signs of active pachymeningitis. In conclusion, our case demonstrates that bilateral optic neuropathy may be the presenting symptom of p-ANCA-associated pachymeningitis, whose causative role may be demonstrated by MRI. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-010-0283-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 639 Titles: – TitleFull: p-ANCA pachymeningitis presenting with isolated "optic neuropathy". Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Salvi F – PersonEntity: Name: NameFull: Mascalchi M – PersonEntity: Name: NameFull: Pasini E – PersonEntity: Name: NameFull: Bartolomei I – PersonEntity: Name: NameFull: Fini N – PersonEntity: Name: NameFull: Marliani F – PersonEntity: Name: NameFull: Malatesta R – PersonEntity: Name: NameFull: Michelucci R – PersonEntity: Name: NameFull: Salvi, Fabrizio – PersonEntity: Name: NameFull: Mascalchi, Mario – PersonEntity: Name: NameFull: Pasini, Elena – PersonEntity: Name: NameFull: Bartolomei, Ilaria – PersonEntity: Name: NameFull: Fini, Nicola – PersonEntity: Name: NameFull: Marliani, Federica – PersonEntity: Name: NameFull: Malatesta, Renato – PersonEntity: Name: NameFull: Michelucci, Roberto IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 31 – Type: issue Value: 5 Titles: – TitleFull: Neurological Sciences Type: main |
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