Aspirin and antiplatelet agent resistance: implications for prevention of secondary stroke.
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| Title: | Aspirin and antiplatelet agent resistance: implications for prevention of secondary stroke. |
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| Authors: | Greer DM (AUTHOR), Greer, David M (AUTHOR) |
| Source: | CNS Drugs. 2010, Vol. 24 Issue 12, p1027-1040. 14p. |
| Abstract: | Oral antiplatelet drugs, including aspirin, clopidogrel and extended-release dipyridamole, are widely prescribed for the secondary prevention of vascular events, including stroke. Despite the benefits of antiplatelet therapy, 10−20% of patients experience a recurrent vascular event while taking antiplatelet medication. This article discusses the concept of antiplatelet resistance in general, focusing on aspirin resistance in particular, as a poorly defined cause of recurrent vascular events. Factors such as the lack of a standardized method to diagnose aspirin resistance and a poor clinical correlation with laboratory assays make the treatment of aspirin nonresponders difficult. In addition, there are confounding conditions such as diabetes mellitus that can affect aspirin resistance and determine a different course of treatment for these patients. Other antiplatelet options may also have resistant subpopulations; thus, alternative strategies for the secondary stroke patient must be explored. [ABSTRACT FROM AUTHOR] |
| Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 104963616 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Aspirin and antiplatelet agent resistance: implications for prevention of secondary stroke. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Greer+DM%22">Greer DM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greer%2C+David+M%22">Greer, David M</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22CNS+Drugs%22">CNS Drugs</searchLink>. 2010, Vol. 24 Issue 12, p1027-1040. 14p. – Name: Abstract Label: Abstract Group: Ab Data: Oral antiplatelet drugs, including aspirin, clopidogrel and extended-release dipyridamole, are widely prescribed for the secondary prevention of vascular events, including stroke. Despite the benefits of antiplatelet therapy, 10−20% of patients experience a recurrent vascular event while taking antiplatelet medication. This article discusses the concept of antiplatelet resistance in general, focusing on aspirin resistance in particular, as a poorly defined cause of recurrent vascular events. Factors such as the lack of a standardized method to diagnose aspirin resistance and a poor clinical correlation with laboratory assays make the treatment of aspirin nonresponders difficult. In addition, there are confounding conditions such as diabetes mellitus that can affect aspirin resistance and determine a different course of treatment for these patients. Other antiplatelet options may also have resistant subpopulations; thus, alternative strategies for the secondary stroke patient must be explored. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=104963616 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.2165/11539160-0000000000-00000 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 1027 Titles: – TitleFull: Aspirin and antiplatelet agent resistance: implications for prevention of secondary stroke. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Greer DM – PersonEntity: Name: NameFull: Greer, David M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 11727047 Numbering: – Type: volume Value: 24 – Type: issue Value: 12 Titles: – TitleFull: CNS Drugs Type: main |
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